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How Enzymes Work From Structure to Function

How Enzymes Work From Structure to Function

The first edition of this book covered the basic treatment of the enzyme reaction using the overall reaction kinetics and stopped-flow method the general properties of protein and cofactors the control of enzyme reaction and the preparation of enzyme protein. These topics are the basis of enzyme research and thus suitable for the beginner in the field. The second edition presents the cofactors produced via the post-translational modification of the enzyme’s active site. These cofactors expand the function of enzymes and open a new research field. The carbonyl reagent phenylhydrazine and related compounds have been useful in finding some of the newly discovered cofactors and thus have been discussed in this edition. The topic of the control of enzyme activity through the channel of substrates and products in polyfunctional enzymes has also been expanded in this book. | How Enzymes Work From Structure to Function

GBP 116.00
1

Mysteries in Muscle Contraction Evidence against Current Dogmas

Mysteries in Muscle Contraction Evidence against Current Dogmas

This book explores the author’s wide-ranging work on muscle research which spans more than 50 years. It delves into the dogmas of muscle contraction: how the models were constructed and what was overlooked during the process including their resulting shortcomings. The text stimulates general readers’ and researchers’ interest highlights the author’s pioneering work on the electron microscopic recording of myosin head power and recovery strokes and presents a frank discussion on how the original work sometimes tends to be overlooked by competing scientists who hinder the progress of science. | Mysteries in Muscle Contraction Evidence against Current Dogmas

GBP 139.00
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A Triple Bottom Line Analysis of Global Consumption Economic Environmental and Social Effects of Pre-Pandemic World Trade 1990–2015

A Triple Bottom Line Analysis of Global Consumption Economic Environmental and Social Effects of Pre-Pandemic World Trade 1990–2015

This book adds a whole new dimension to the editors’ previous work on the social economic and environmental effects of global trade. For the first time it brings all three pillars of sustainability together into one coherent multiregional input–output (MRIO) framework. It shows the power of MRIO analysis to illuminate the local and global interdependencies of economic environmental and social systems and the benefits to be gained through analysing all three together. Change one thing and everything else changes. With chapters from around 60 researchers across 34 countries this book illustrates the effect of natural resources and government policy settings 1990–2015 on the balancing act that was—and is—global trade. It provides a holistic systems’ view of how supply chains work revealing how easily they can become fragmented and out of kilter. And within all the chaos of COVID-19 it shows how MRIO is the one tool that can help rebuild a post-pandemic global economy into a fairer safer world. | A Triple Bottom Line Analysis of Global Consumption Economic Environmental and Social Effects of Pre-Pandemic World Trade 1990–2015

GBP 116.00
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The Hip Joint Modified Posterior Approach

The Hip Joint Modified Posterior Approach

This book summarizes the lifetime work of Dr K. Mohan Iyer and is based on his research done at the University of Liverpool UK where he devised a modified posterior approach to the hip joint and has been following it from 1981 till today. The book discusses the anterior approach to the hip on a standard operating table using a leg holder with a combined spinal anesthetic and general anesthetic. It studies total hip replacement as a day-case as an evolution in total hip replacement and presents the principles of anterior approach for total hip arthroplasty including discussions on the choice of patients superficial and deep dissection and dedicated surgical instruments. It provides extensive details on the direct anterior approach (DAA) and shows how the DAA to the hip can be carried out on a plain table which can be useful in countries in Asia such as India without the use of special operating tables and dedicated surgical instruments for the same. The book is helpful for the upcoming postgraduates in orthopedics anywhere in the world to be well versed in DAA to the hip joint. | The Hip Joint Modified Posterior Approach

GBP 193.00
1

Environmental Ethical and Economical Issues of Nanotechnology

Environmental Ethical and Economical Issues of Nanotechnology

Nanotechnology is moving out of its comfort zone of scientific discourse. As new products go to market and national and international organizations roll out public-engagement programs on nanotechnology to discuss environmental and health issues various sectors of the public are beginning to discuss what the controversy is all about. Nongovernmental organizations have long since reacted; however now the social sciences have begun to study the cultural phenomenon of nanotechnology thus extending discourses and opening out nanotechnology to whole new social dimensions. These dimensions and their newly constructed imaginings around nanotechnology intersect with the ecology health governance economy and illusory futures. There is always a need for more than just an ELSI (ethical legal and social implications) sideshow within nanotechnology. The collective public imaginings of nanotechnology include tangles of science and science fiction local enterprises and global transformation all looking forward toward a sustainable future while looking back on the past debates on science and nature. This book highlights the environmental health and economical concerns of nanotechnology and discusses its future research directions. It provides academia and industry a high-tech start-up that will revolutionize modern practices. With little and outdated literature available on the topic this timely book will be helpful for the readers as it thoroughly covers the environmental ethical and economical issues of nanotechnology.

GBP 76.99
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Transparent Semiconducting Oxides Bulk Crystal Growth and Fundamental Properties

Transparent Semiconducting Oxides Bulk Crystal Growth and Fundamental Properties

This book discusses various aspects of different bulk TSO single crystals in terms of thermodynamics; bulk crystal growth using diverse techniques involving gas phase solution and melt; and the resulting crystal size appearance and structural quality as well as the fundamental properties that were gathered from bulk single crystals. It presents experimental results accompanied by theoretical results such as band structure and native defects. Combinations of various bulk single crystals along with their properties show great promise in practical device functionality and fabrication. Many TSO-based devices have already been demonstrated in several technical areas including electronics optoelectronics and photovoltaics as well as sensing devices. The book is the first of its kind that brings together a variety of bulk single crystals of scientifically and technically important TSOs along with their properties which may result in novel devices with unique functionalities. | Transparent Semiconducting Oxides Bulk Crystal Growth and Fundamental Properties

GBP 170.00
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Nano-Enabled Medical Applications

Nano-Enabled Medical Applications

This book is the second in a series presenting articles that received the most citations in recent years in nanomedicine. The series is edited by a prominent nanotechnology researcher and editor-in-chief of Precision Nanomedicine. The theme of the second volume is about nano-enabled medical applications. The 19 articles collected here have already acquired more than 12 500 citations highlighting the importance and professional recognition of the work of these scientists in nanomedicine. The content includes the general overview of the field and a wide variety of applications that have been impossible without nanoscience and nanotechnology.

GBP 193.00
1

Ceramic Fibers and Their Applications

Ceramic Fibers and Their Applications

To date several polymer-derived ceramic fibers have been developed all over the world out of which SiC fibers synthesized from polycarbosilane and their derivatives have achieved highest heat resistance and show excellent mechanical properties. Their use in ceramic matrix composite materials has resulted in high-temperature stability and light weight which show great promise in next-generation applications such as aerospace engines. This book presents polymer-derived ceramic fibers from a historical viewpoint; basic information about them such as production process fine structures and physical properties; their applications; and prospects of future inorganic fibers. | Ceramic Fibers and Their Applications

GBP 76.99
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Physics and Future of Hurricanes

Physics and Future of Hurricanes

This monograph is about hurricanes prompted by a discovery that suggests they will become more powerful with global warming. It provides at a college physics level a basic understanding of hurricanes emphasizing the flow of energy into and out of these storms and as a textbook covers some material that might be taught in meteorology or atmospheric physics courses. The text is centered on a new discovery that is not in any existing textbook. Because of the new discovery the book is of immediate interest to all meteorologists. It turns out that hurricanes as revealed by the new discovery are usefully regarded as a separate phase of matter bringing in characteristic temperature dependences near their transitions. The role of phase change in understanding hurricanes brings in the 20th-century discoveries in theoretical physics relating to critical phenomena with non-intuitive values of the critical exponent β entering the formula P = const (T – Tc)β where P is a characteristic strength parameter or order parameter of the phase of matter appearing at Tc. According to the new discovery on hurricanes it appears that taking the wind velocity as the order parameter P the critical exponent is near 1/3. In a second discovery we find that a small correction to this value is brought in by the complicated physics of the renormalization group that earned K. G. Wilson the Nobel Prize in Physics in 1982. | Physics and Future of Hurricanes

GBP 53.99
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Topological Quantum Materials Concepts Models and Phenomena

Topological Quantum Materials Concepts Models and Phenomena

In topological quantum materials quantum effects emerge at macroscopic scales and are robust to continuous changes in a material’s state. This striking synergy between quantum and topological properties is of great interest for both fundamental research and emerging technologies especially in the fields of electronics and quantum information. This edition of the book presents a wealth of topological quantum materials bringing together burgeoning research from different areas: topological insulators transition metal dichalcogenides Weyl semimetals and unconventional and topological superconductors. The realization of the application potential of topological quantum materials requires understanding their properties at a fundamental level. This brings us back to the discovery of topological phases of matter which earned the Nobel Prize in Physics in 2016. This book explores the connection between pioneering work on topological phases of matter and a flurry of activity that followed. The topics covered include the quantum anomalous and spin Hall effects emergent axion electrodynamics and topological magnetoelectric effects Weyl nodes and surface Fermi arcs weak antilocalization induced triplet superconductivity Majorana fermion modes and the fractional Josephson effect. | Topological Quantum Materials Concepts Models and Phenomena

GBP 139.00
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Radiation in Medicine and Biology

Radiation in Medicine and Biology

This book focuses on the conventional and emerging applications of radiations which include radio waves and ultraviolet and gamma radiations. It discusses new techniques in radiation therapy and the effects of ionizing radiations on biological systems. The applications of radiations in the synthesis and use of nanoparticles along with the effects of hypergravity indicate a new trend. The book offers a concise account of the latest studies carried out so far and shows the new initiatives to be undertaken in the field of medicine and biology. It covers the medical use of radiations such as ferrous sulfate–benzoic acid–xylenol orange dosimetry Co-60 tomotherapy radio-electro-chemotherapy and fractional radiotherapy and radiobiological effects such as the effects of cell phone radiations on human health parameters and the combined effects of radiations and hypergravity on plants. | Radiation in Medicine and Biology

GBP 95.00
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Introduction to Limb Arthrology

Introduction to Limb Arthrology

This book discusses arthrology in general and of the upper and lower limbs specifically. It covers the examination of each joint of both limbs considering their basic anatomy and physiology. It presents the various tests required for examining the joints and articulations and the systematic approaches that should be followed in cases of diagnosis of diseases and injuries related to them as well as in specific cases of disease and injuries. The book also defines special tests required in varied situations and mentions precautions that should be taken while examining patients of specific ages or work groups. To simplify the explanation and promote education original photographs either documented during clinical examination of the foot and ankle or taken using models are used in this book. These photographs are from accomplished orthopedic surgeons and have not been documented anywhere before. In addition some chapters showcase line diagrams sketched to illustratively discuss the information being presented. The book will help readers understand the importance of this expanding sub-specialty in orthopedics and will be useful for orthopedic surgeons taking exams in different universities of the world as well as sub-speciality exams of each joint. | Introduction to Limb Arthrology

GBP 216.00
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Lipid-Based Drug Delivery Systems Principles and Applications

Lipid-Based Drug Delivery Systems Principles and Applications

This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability. It covers the latest developments and advancements in the field of drug delivery and explores and compiles information on the current situation of lipid-based formulations used as versatile excipients and all their possible routes to improve therapeutic benefits. The book discusses novel formulations such as depot formulations micro- and nanoemulsions solid lipid nanoparticles (SLNs) nanostructured lipid carriers (NLCs) liposomes nanoliposomes micelles nanosuspensions lipid implants and inserts and lipid nanotubes. It presents preparation methods of LBDDSs and their physicochemical properties and portrays their various application angles and their impacts on drug-conveyance frameworks when employed in vitro and in vivo. The book is beneficial for researchers working on lipid-based drug formulations as well as biological and translational drug delivery. It is also a useful resource for course work of students of various academic degree programs such as pharmacy health sciences biotechnology and microbiology; postgraduate and PhD students; and postdoctoral fellows researching on nanomedicine-based drug delivery systems. | Lipid-Based Drug Delivery Systems Principles and Applications

GBP 270.00
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Musical Spaces Place Performance and Power

Musical Spaces Place Performance and Power

There is growing recognition and understanding of music’s fundamentally spatial natures with significances of space found both in the immediacy of musical practices and in connection to broader identities and ideas around music. Whereas previous publications have looked at connections between music and space through singular lenses (such as how they are linked to ethnic identities or how musical images of a city are constructed) this book sets out to explore intersections between multiple scales and kinds of musical spaces. It complements the investigation of broader power structures and place-based identities by a detailed focus on the moments of music-making and musical environments revealing the mutual shaping of these levels. The book overcomes a Eurocentric focus on a typically narrow range of musics (especially European and North American classical and popular forms) with case studies on a diverse set of genres and global contexts inspiring a range of ethnographic text-based historical and practice-based approaches. | Musical Spaces Place Performance and Power

GBP 76.99
1

Byzantine Coins Influenced by the Shroud of Christ

Byzantine Coins Influenced by the Shroud of Christ

Numerous studies have been carried out on Byzantine coins but there are still no univocal interpretations on the details of the figures represented there and in particular on those relating to Jesus Christ. The information derived from the studies on the Holy Shroud the most important Relic of Christ in Christianity has clearly resulted in some new interpretations. This is the first book in the world that deals extensively with the effigy of Christ despite being the most sought after and collected by numismatists. Furthermore the book relates the different images of the Redeemer on Byzantine coins with the image of Jesus Christ on the Shroud the most important Relic of Christianity. The numerous collectors will therefore be interested in having not only a numismatic analysis of these coins but also a historical-religious study. This book which should be understandable to everyone demonstrates the strong influence that the Shroud had in the Byzantine era. | Byzantine Coins Influenced by the Shroud of Christ

GBP 100.00
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Semi-Critical Assisted Extraction Applications and Commercialization in Biotechnology Food and Pharmacy

Semi-Critical Assisted Extraction Applications and Commercialization in Biotechnology Food and Pharmacy

In the past three decades great efforts have been made to develop new methods for the extraction of natural molecules. Improved extraction technologies have garnered scientific interest as they have helped in understanding how mass and energy transfer exhibited for a solvent and solute during a chemical extraction can be used as physical chemistry parameters leading to the modeling and design of new advantageous equipment. In situ data collected during a chemically assisted experiment is useful in a variety of scientific and technological applications especially in generating extractors that are safer more efficient and offer true opportunities to scale them up in a wide range of materials (among stainless steel). This book compiles empirical and traditional extraction methods applied to cutting-edge critical extraction research in the areas of food science phytochemistry pharmacy fragrance cosmetology and folk medicine. It presents extraction technology as an interdisciplinary area that applies the principles of physics and chemistry as tools to develop engineered models for the construction of more advanced extraction devices. It includes examples and problems related to data treatment in normal laboratory research work that will facilitate undergraduate- and graduate-level students as well as operators working in the area in solving real problems. | Semi-Critical Assisted Extraction Applications and Commercialization in Biotechnology Food and Pharmacy

GBP 116.00
1

The Shroud of Turin First Century after Christ

The Shroud of Turin First Century after Christ

The Shroud of Turin is the most important and studied relic in the world. The many scientific studies on the relic until today have failed to provide conclusive answers about the identity of the enveloped man and the dynamics regarding the image impressed therein. This book not only addresses these issues in a scientific and objective manner but also leads the reader through new search paths. In the second edition besides including some of the most recent findings on the Shroud the authors follow the many tips and comments received from readers. The Shroud’s dating by means of alternative methods has not been free from controversies some of which have even implied the non-authenticity of the Shroud’s samples tested. So the authors duly expand Chapter 7 to include the proof of the origin of the samples used in the recent scientific research and also address the provenance and the path of the original sample. Furthermore a new section contains a personal interview with the authors that is the result of the interesting and praiseworthy work of a Bavarian high school student. Although there are many books on the subject none contains such a formidable quantity of scientific news and reports. Unique in its genre this book is a powerful tool for those who want to study the Turin Shroud deeply. | The Shroud of Turin First Century after Christ

GBP 61.99
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Bulk and Surface Acoustic Waves Fundamentals Devices and Applications

Bulk and Surface Acoustic Waves Fundamentals Devices and Applications

This book introduces acoustic wave theories using a reader-friendly matrix-based linear algebra approach. It will enable the reader to take advantage of software tools such as MATLAB (commercial codes) and OCTAVE (open-source codes) to gain better and deeper understanding of the underlying physics quickly. In this aspect this text can be regarded as a practical introduction of the acoustic wave theories in an easy-to-follow linear algebra format using matrix manipulations instead of an abstract approach relying on tensor manipulations. The book also uses case studies to demonstrate how the fundamentals on acoustic waves discussed throughout the book are applied in device designs and analyses such that the connections and interdependences between the underlying sciences and the observed behavior and performances can be better appreciated by the reader. To achieve this all problems for illustrations examples case studies and device analyses are developed and solved based on the mathematical foundations laid out in the book. | Bulk and Surface Acoustic Waves Fundamentals Devices and Applications

GBP 139.00
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Clinical Biochemistry A Laboratory Guide

Clinical Biochemistry A Laboratory Guide

A knowledge of the practical aspects of clinical biochemistry is essential for medical students to understand the diagnostic and prognostic status of any ailment. This book addresses and compiles some of the invariably used protocols in biochemistry with the aim to enhance the understanding of the basics behind following the methodologies including those for urine analysis; carbohydrate protein and lipid analyses; and diabetes and lipid profile. It discusses organ function tests such as liver renal or pancreatic function tests in addition to exploring pH and buffer colorimeter spectrophotometer chromatography electrophoresis enzyme-linked adsorbent assay radioimmunoassay biosensor/glucometer fructosamine DNA isolation mass spectrometry flow cytometry centrifugation automation cerebrospinal fluid examination and oxalic acid test. The book also touches upon the basics of laboratory safety rules and laboratory glassware. The book is helpful for students to understand the relationship between quality management and specimen collection and processing them for their biological functions. It is well-suited for academic courses including undergraduate graduate postgraduate and professional courses and covers the practical syllabus for MBBS BDS BSc MLT BSc nursing and MSc students. For undergraduate students in the disciplines of biochemistry molecular biology chemistry and other related biological sciences the book forms an integral part of the syllabus with its case studies MCQs biochemistry OSPEs etc. It also demonstrates the actual experiments for understanding the concepts better and is a must read for students to acquire skills to work with a clinical biochemistry laboratory. | Clinical Biochemistry A Laboratory Guide

GBP 76.99
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The Newman Lectures on Thermodynamics

The Newman Lectures on Thermodynamics

Prof. Newman is considered one of the great chemical engineers of his time. His reputation derives from his mastery of all phases of the subject matter his clarity of thought and his ability to reduce complex problems to their essential core elements. He has been teaching undergraduate and graduate core subject courses at the University of California Berkeley (UC Berkeley) USA since joining the faculty in 1966. His method is to write out in long form everything he expects to convey to his class on a subject on any given day. He has maintained and updated his lecture notes from notepad to computer throughout his career. This book is an exact reproduction of those notes. The book presents concepts needed to define single- and multi-component systems starting with the Gibbs function. It helps readers derive concepts of entropy and temperature and the development of material properties of pure substances. It acquaints them with applications of thermodynamics such as cycles open systems and phase transitions and eventually leads them to concepts of multiple-component systems in particular chemical and phase equilibria. It clearly presents all concepts that are necessary for engineers. | The Newman Lectures on Thermodynamics

GBP 37.99
1

Biochemical Engineering A Laboratory Manual

Biochemical Engineering A Laboratory Manual

Biochemical engineering mostly deals with the most complicated life systems as compared with chemical engineering. A fermenter is the heart of biochemical processes. It is essential to operate a system properly. A description of enzymatic reaction kinetics is followed by cell growth kinetics to determine several kinetic parameters. Operations and analyses of several biochemical processes are included to determine their special. The book also covers the determination of several operational parameters such as volumetric mass transfer coefficient mixing time death rate constant chemical oxygen demand and heat of combustion. This book provides a novel description of the experimental protocol to find out several operational parameters of biochemical processes. A comprehensive collection of numerous experiments based on fundamentals it focuses on the determination of not only the characteristics of raw materials but also other essential parameters required for the operation of biochemical processes. It also emphasizes the applicability of the analysis to various processes. Equipped with illustrative diagrams neat flowcharts and exhaustive tables the book is ideal for young researchers teachers and scientists working towards developing a solid understanding of the experimental aspects of biochemical engineering. | Biochemical Engineering A Laboratory Manual

GBP 76.99
1

Strongly Correlated Electrons in Two Dimensions

Strongly Correlated Electrons in Two Dimensions

The properties of strongly correlated electrons confined in two dimensions are a forefront area of modern condensed matter physics. In the past two or three decades strongly correlated electron systems have garnered a great deal of scientific interest due to their unique and often unpredictable behavior. Two of many examples are the metallic state and the metal–insulator transition discovered in 2D semiconductors: phenomena that cannot occur in noninteracting systems. Tremendous efforts have been made in both theory and experiment to create an adequate understanding of the situation; however a consensus has still not been reached. Strongly Correlated Electrons in Two Dimensions compiles and details cutting-edge research in experimental and theoretical physics of strongly correlated electron systems by leading scientists in the field. The book covers recent theoretical work exploring the quantum criticality of Mott and Wigner–Mott transitions experiments on the metal–insulator transition and related phenomena in clean and dilute systems the effect of spin and isospin degrees of freedom on low-temperature transport in two dimensions electron transport near the 2D Mott transition experimentally observed temperature and magnetic field dependencies of resistivity in silicon-based systems with different levels of disorder and microscopic theory of the interacting electrons in two dimensions. Edited by Sergey Kravchenko a prominent experimentalist this book will appeal to advanced graduate-level students and researchers specializing in condensed matter physics nanophysics and low-temperature physics especially those involved in the science of strong correlations 2D semiconductors and conductor–insulator transitions.

GBP 85.99
1

Competitive Math for Middle School Algebra Probability and Number Theory

Competitive Math for Middle School Algebra Probability and Number Theory

The 39 self-contained sections in this book present worked-out examples as well as many sample problems categorized by the level of difficulty as Bronze Silver and Gold in order to help the readers gauge their progress and learning. Detailed solutions to all problems in each section are provided at the end of each chapter. The book can be used not only as a text but also for self-study. The text covers algebra (solving single equations and systems of equations of varying degrees algebraic manipulations for creative problem solving inequalities basic set theory sequences and series rates and proportions unit analysis and percentages) probability (counting techniques introductory probability theory more set theory permutations and combinations expected value and symmetry) and number theory (prime factorizations and their applications Diophantine equations number bases modular arithmetic and divisibility). It focuses on guiding students through creative problem-solving and on teaching them to apply their knowledge in a wide variety of scenarios rather than rote memorization of mathematical facts. It is aimed at but not limited to high-performing middle school students and goes further in depth and teaches new concepts not otherwise taught in traditional public schools. | Competitive Math for Middle School Algebra Probability and Number Theory

GBP 18.99
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Analysis of Structures by Matrix Methods

Analysis of Structures by Matrix Methods

The analysis of engineering structures has always been a challenge to engineers and in the past classical methods were used to quantify the response of a structure to the applied forces. These methods were suitable for the analysis of relatively simple structures that could be solved by hand calculations but complicated structures had to be simplified to a model that could be solved by classical methods. The results however were approximations depending on the modifications made to the structure as well as on the experience and judgement of the analyst. These limitations led to the derivation of the slope-deflection equations for continuous beams and later formulation of the moment distribution method. With the advent of electronic computers systematic procedures for the analysis of structures have been developed. Computer programs help in obtaining required solutions to the simultaneous equations in the case of structures where the number of equations is large and hand calculations are not suitable. The detailed work with simultaneous equations can be made in a general and compact form by using matrix notation leading to the development of the matrix methods of structural analysis. This book deals with the analysis of engineering structures made of skeletal members and covers the type of structures that are commonly used in practice. It builds up on the subject matter dealing with matrix algebra analysis of bar elements special forms of members stability and vibration of structures and pin-connected rigid-plane and 3D frames. It treats the important step of formulating the overall stiffness matrix of a structure in a systematic and straightforward manner and uses simple mathematical approaches wherever possible. The book is reader friendly particularly for beginners who have no prior knowledge in this subject and can also be used as a textbook by undergraduate and postgraduate students studying for a degree in civil structural or mechanical engineering as well as by practicing engineers who have not studied this subject but are using software packages that deal with the analysis of engineering structures. | Analysis of Structures by Matrix Methods

GBP 139.00
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Three Daughters Three Journeys Quest for Cancer Cure

Three Daughters Three Journeys Quest for Cancer Cure

Cancer threatens the lives of people around the world. Women in particular are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60 these inheritable cancers threaten women’s lives health and fertility even when they are young before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena a Polish oncology nurse has spent her life treating child patients with cancer. Then she confronts it in her own family and her own body. Kamola a rural Indian girl knows she has symptoms of the same disease that took her mother but feels afraid to discuss it with her father and brothers knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra a doctor testing a new treatment called Neelazin using a bacterial anticancer protein in food to destroy cancer cells. Selena a wealthy woman of color in Chicago finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs as these drugs can enter both normal and cancer cells though preferably cancer cells causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets thereby becoming resistant to the drugs as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer rather than removing the healthy tissue of the breasts and ovaries. Hopefully they would not have to choose between fertility and survival as is the implied message in this book fictional as it is at this time. | Three Daughters Three Journeys Quest for Cancer Cure

GBP 31.99
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