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The Shroud of Christ Evidence of a 2 000 Year Antiquity

The Shroud of Christ Evidence of a 2 000 Year Antiquity

The Shroud of Turin has been the focus of extensive study by historians and researchers since the beginning of the twentieth century. It is possibly the world’s most studied historical artifact generating a regular flow of new research publications. There is however one scientific test that overshadows all other research: the 1988 radiocarbon dating. This test dated the cloth to the period 1260–1390AD and was given such extensive publicity that most people today no longer accept the Shroud to be a true relic. Sadly very few people are aware that this test has been widely criticized for falling short of acceptable scientific standards. Similarly most people remain unaware of the wealth of compelling evidence that contradicts the conclusions of that test and supports claims of the Shroud’s authenticity. This book reveals extracts from secret discussions on dating evidence from the Shroud Science Group a private international forum of Shroud researchers and provides a detailed account of the dating evidence revealed by over a hundred years of research. It outlines reasons why the 1988 radiocarbon dating test continues to attract criticism from respected scientists and also describes a series of innovative flax dating techniques which have recently been used measure the age of Shroud material producing results that contradict the radiocarbon date. | The Shroud of Christ Evidence of a 2 000 Year Antiquity

GBP 61.99
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Research Methodologies for Beginners

Research Methodologies for Beginners

This textbook introduces the general points of view of research methodology in the scientific and engineering fields of studies and presents an overview of the technical and professional communication needed for article publication in journals. It comprises several practice exercises that will give beginners the confidence to move on the communicative activities. Every chapter provides problem sets that will help readers check their understanding of each concept. The book will also help readers formulate specific research topics research questions and hypotheses; conduct literature reviews relevant to the research topics; develop applicable research methodologies; and write and present their research outlining the key elements of the proposed projects. It is very useful for students and researchers opting for a course on research methodology and for seminars at undergraduate and graduate levels. | Research Methodologies for Beginners

GBP 44.99
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Cancer Genetics and Genomics for Personalized Medicine

Cancer Genetics and Genomics for Personalized Medicine

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy or precision medicine or personalized medicine is becoming a standard treatment for many diseases including cancer. However how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students professional researchers and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung gastric liver breast and other types of cancers. Circulating tumor cell cell-free circulating DNA and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy followed by new emerging fields of hereditary cancer thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

GBP 108.00
1

Microbial Infections and Cancer Therapy

Microbial Infections and Cancer Therapy

This book deals with the emerging concept that certain pathogenic bacteria and viruses when infecting people with cancer actively fight tumors allowing their regression. Although such observations go back more than 100 years use of specific bacterial strains or viruses usually genetically modified with known anticancer drugs and their protein/peptide products has gained ground in recent years allowing significant cancer regression in clinical trials with stage III/IV cancer patients or even in pediatric brain tumor patients often without any demonstration of toxicity. It is composed of 12 chapters written by pioneers in microbial biotech and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies. Such combinatorial therapies have gained particular attention as a strategy to overcome drug resistance and the readers of the book will discover their impact on fundamental research and promising results from clinical trials. | Microbial Infections and Cancer Therapy

GBP 139.00
1

Multifragmentation in Heavy-Ion Reactions Theory and Experiments

Multifragmentation in Heavy-Ion Reactions Theory and Experiments

This book provides a collection of reviews of some of the recent developments in nuclear physics research at intermediate energies from across the globe. It especially focuses on the most essential aspects such as multifragmentation and associated phenomena in nuclear collisions with the incident energy region between a few MeV and several hundreds of MeV/nucleon. The topic of the book—multifragmentation—was chosen based on the fact that all heavy-ion collisions revolve around a fragmenting system which is also thought to have a link to phase transitions. One unique and valuable dimension of this book is that it has brought together the research of several experts working in the field of intermediate energy heavy-ion collisions in various renowned laboratories of the world. It provides a thorough review of the recent developments in various related phenomena especially multifragmentation observed at the intermediate-energy range both theoretically and experimentally. It extensively discusses the concept of nuclear symmetry energy which is important for the nuclear physics and astrophysics communities. In addition the book identifies potential research directions and technologies that will drive future innovations. It will serve as a valuable reference for a larger audience including students who wish to pursue a career in nuclear physics and astrophysics. | Multifragmentation in Heavy-Ion Reactions Theory and Experiments

GBP 154.00
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Immunoassays Development Applications and Future Trends

Immunoassays Development Applications and Future Trends

The concept behind this book is to provide a detailed and practical overview of the development and use of immunoassays in many different areas. Immunoassays are analytical tests that utilise antibodies to measure the amount activity or identity of an analyte. This book is designed to provide a critical and helpful insight into the subject and to give the user practical information that may be of assistance in assay format selection antibody generation/selection and choice of appropriate detection strategies. It is comprised of 13 chapters written by highly experienced researchers in the fields of antibody-based research immunoassay development assay validation diagnostics and microfluidics. Beginning with a comprehensive survey of antibodies immunoassay formats and signalling systems the book elucidates key topics related to the development of an ideal antibody-based sensor focuses on the important topic of surface modification explores key parameters in the immobilisation of antibodies onto solid surfaces discusses the move to ‘lab-on-a-chip’-based devices and investigates the key parameters necessary for their development. Three of the chapters are dedicated to the areas of clinical diagnostics infectious disease monitoring and food security where immunoassay-based applications have become highly valuable tools. The future of immunoassays including next-generation immunoassays electrochemical-immunoassays and ‘lab-on-a-chip’-based systems is also discussed. The book also covers the use of optical detection systems (with a focus on surface plasmon resonance) in immunoassays provides a compilation of important routinely used immunoassay protocols and addresses problems that may be encountered during assay development. | Immunoassays Development Applications and Future Trends

GBP 159.00
1

Mobile Microspies Particles for Sensing and Communication

Mobile Microspies Particles for Sensing and Communication

On the one hand particle-based sensing techniques are driven by new technologies for preparing and measuring micro- and nanoparticles and by a fascination of the possibilities for design and functionalization of all specificities in structure shapes and behavior of these tiny objects. On the other hand there evolves a fast-growing need for new sensing and communication paths for medicine biotechnology and analytical science as well as for new and efficient information transfer and storage systems. No longer are particles regarded only as special types of materials. However we have a better understanding of how they are bridging the gap between material and system between structure and function. Although there are numerous books on micro- and nanoparticles and on sensors there is to the best of my knowledge no book focusing on the general concept of particles as mobile microtransducers. This book clarifies that signal-transducing particles should be regarded as functional elements as part of a system not simply as special materials. It introduces concepts of bead-base sensing and mobile spies at the micro- and nanoscale and gives a representative overview of the variety of particle-based sensing. The state of the art in the development of particles as mobile spies for communication and information management allows us to speculate about future particle-based components and systems in a completely sustainable world economy. In addition the book reports on a fast-evolving technical field which is a typical example of the required convergence of technical strategies and mechanisms in living nature and would make a great reference for professionals and students of chemistry biochemistry biology pharmacy medicine agriculture mechatronics informatics materials science and systems engineering. | Mobile Microspies Particles for Sensing and Communication

GBP 100.00
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Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer β-Lactams and related compounds as antibacterials non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy. | Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

GBP 193.00
1

Gallium Nitride Power Devices

Gallium Nitride Power Devices

GaN is considered the most promising material candidate in next-generation power device applications owing to its unique material properties for example bandgap high breakdown field and high electron mobility. Therefore GaN power device technologies are listed as the top priority to be developed in many countries including the United States the European Union Japan and China. This book presents a comprehensive overview of GaN power device technologies for example material growth property analysis device structure design fabrication process reliability failure analysis and packaging. It provides useful information to both students and researchers in academic and related industries working on GaN power devices. GaN wafer growth technology is from Enkris Semiconductor currently one of the leading players in commercial GaN wafers. Chapters 3 and 7 on the GaN transistor fabrication process and GaN vertical power devices are edited by Dr. Zhihong Liu who has been working on GaN devices for more than ten years. Chapters 2 and 5 on the characteristics of polarization effects and the original demonstration of AlGaN/GaN heterojunction field-effect transistors are written by researchers from Southwest Jiaotong University. Chapters 6 8 and 9 on surface passivation reliability and package technologies are edited by a group of researchers from the Southern University of Science and Technology of China. | Gallium Nitride Power Devices

GBP 139.00
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