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Statistics and Health Care Fraud How to Save Billions

Statistics and Health Care Fraud How to Save Billions

Statistics and Health Care Fraud: How to Save Billions helps the public to become more informed citizens through discussions of real world health care examples and fraud assessment applications. The author presents statistical and analytical methods used in health care fraud audits without requiring any mathematical background. The public suffers from health care overpayments either directly as patients or indirectly as taxpayers and fraud analytics provides ways to handle the large size and complexity of these claims. The book starts with a brief overview of global healthcare systems such as U. S. Medicare. This is followed by a discussion of medical overpayments and assessment initiatives using a variety of real world examples. The book covers subjects as: • Description and visualization of medical claims data • Prediction of fraudulent transactions • Detection of excessive billings • Revealing new fraud patterns • Challenges and opportunities with health care fraud analytics Dr. Tahir Ekin is the Brandon Dee Roberts Associate Professor of Quantitative Methods in McCoy College of Business Texas State University. His previous work experience includes a working as a statistician on health care fraud detection. His scholarly work on health care fraud has been published in a variety of academic journals including International Statistical Review The American Statistician and Applied Stochastic Models in Business and Industry. He is a recipient of the Texas State University 2018 Presidential Distinction Award in Scholar Activities and the ASA/NISS y-Bis 2016 Best Paper Awards. He has developed and taught courses in the areas of business statistics optimization data mining and analytics. Dr. Ekin also serves as Vice President of the International Society for Business and Industrial Statistics. | Statistics and Health Care Fraud How to Save Billions

GBP 24.99
1

Bayesian Designs for Phase I-II Clinical Trials

Bayesian Designs for Phase I-II Clinical Trials

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time if promising preclinical results do not translate into a real treatment advance it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center this book shows how Bayesian designs for early-phase clinical trials can explore refine and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity. | Bayesian Designs for Phase I-II Clinical Trials

GBP 38.99
1

Bayesian Applications in Pharmaceutical Development

Bayesian Applications in Pharmaceutical Development

The cost for bringing new medicine from discovery to market has nearly doubled in the last decade and has now reached $2. 6 billion. There is an urgent need to make drug development less time-consuming and less costly. Innovative trial designs/ analyses such as the Bayesian approach are essential to meet this need. This book will be the first to provide comprehensive coverage of Bayesian applications across the span of drug development from discovery to clinical trial to manufacturing with practical examples. This book will have a wide appeal to statisticians scientists and physicians working in drug development who are motivated to accelerate and streamline the drug development process as well as students who aspire to work in this field. The advantages of this book are: Provides motivating worked practical case examples with easy to grasp models technical details and computational codes to run the analyses Balances practical examples with best practices on trial simulation and reporting as well as regulatory perspectives Chapters written by authors who are individual contributors in their respective topics Dr. Mani Lakshminarayanan is a researcher and statistical consultant with more than 30 years of experience in the pharmaceutical industry. He has published over 50 articles technical reports and book chapters besides serving as a referee for several journals. He has a PhD in Statistics from Southern Methodist University Dallas Texas and is a Fellow of the American Statistical Association. Dr. Fanni Natanegara has over 15 years of pharmaceutical experience and is currently Principal Research Scientist and Group Leader for the Early Phase Neuroscience Statistics team at Eli Lilly and Company. She played a key role in the Advanced Analytics team to provide Bayesian education and statistical consultation at Eli Lilly. Dr. Natanegara is the chair of the cross industry-regulatory-academic DIA BSWG to ensure that Bayesian methods are appropriately utilized for design and analysis throughout the drug-development process. | Bayesian Applications in Pharmaceutical Development

GBP 44.99
1

Handbook of Approximation Algorithms and Metaheuristics Methologies and Traditional Applications Volume 1

Handbook of Approximation Algorithms and Metaheuristics Methologies and Traditional Applications Volume 1

Handbook of Approximation Algorithms and Metaheuristics Second Edition reflects the tremendous growth in the field over the past two decades. Through contributions from leading experts this handbook provides a comprehensive introduction to the underlying theory and methodologies as well as the various applications of approximation algorithms and metaheuristics. Volume 1 of this two-volume set deals primarily with methodologies and traditional applications. It includes restriction relaxation local ratio approximation schemes randomization tabu search evolutionary computation local search neural networks and other metaheuristics. It also explores multi-objective optimization reoptimization sensitivity analysis and stability. Traditional applications covered include: bin packing multi-dimensional packing Steiner trees traveling salesperson scheduling and related problems. Volume 2 focuses on the contemporary and emerging applications of methodologies to problems in combinatorial optimization computational geometry and graphs problems as well as in large-scale and emerging application areas. It includes approximation algorithms and heuristics for clustering networks (sensor and wireless) communication bioinformatics search streams virtual communities and more. About the EditorTeofilo F. Gonzalez is a professor emeritus of computer science at the University of California Santa Barbara. He completed his Ph. D. in 1975 from the University of Minnesota. He taught at the University of Oklahoma the Pennsylvania State University and the University of Texas at Dallas before joining the UCSB computer science faculty in 1984. He spent sabbatical leaves at the Monterrey Institute of Technology and Higher Education and Utrecht University. He is known for his highly cited pioneering research in the hardness of approximation; for his sublinear and best possible approximation algorithm for k-tMM clustering; for introducing the open-shop scheduling problem as well as algorithms for its solution that have found applications in numerous research areas; as well as for his research on problems in the areas of job scheduling graph algorithms computational geometry message communication wire routing etc. | Handbook of Approximation Algorithms and Metaheuristics Methologies and Traditional Applications Volume 1

GBP 44.99
1

Statistical Machine Learning A Unified Framework

Statistical Machine Learning A Unified Framework

The recent rapid growth in the variety and complexity of new machine learning architectures requires the development of improved methods for designing analyzing evaluating and communicating machine learning technologies. Statistical Machine Learning: A Unified Framework provides students engineers and scientists with tools from mathematical statistics and nonlinear optimization theory to become experts in the field of machine learning. In particular the material in this text directly supports the mathematical analysis and design of old new and not-yet-invented nonlinear high-dimensional machine learning algorithms. Features: Unified empirical risk minimization framework supports rigorous mathematical analyses of widely used supervised unsupervised and reinforcement machine learning algorithms Matrix calculus methods for supporting machine learning analysis and design applications Explicit conditions for ensuring convergence of adaptive batch minibatch MCEM and MCMC learning algorithms that minimize both unimodal and multimodal objective functions Explicit conditions for characterizing asymptotic properties of M-estimators and model selection criteria such as AIC and BIC in the presence of possible model misspecification This advanced text is suitable for graduate students or highly motivated undergraduate students in statistics computer science electrical engineering and applied mathematics. The text is self-contained and only assumes knowledge of lower-division linear algebra and upper-division probability theory. Students professional engineers and multidisciplinary scientists possessing these minimal prerequisites will find this text challenging yet accessible. About the Author: Richard M. Golden (Ph. D. M. S. E. E. B. S. E. E. ) is Professor of Cognitive Science and Participating Faculty Member in Electrical Engineering at the University of Texas at Dallas. Dr. Golden has published articles and given talks at scientific conferences on a wide range of topics in the fields of both statistics and machine learning over the past three decades. His long-term research interests include identifying conditions for the convergence of deterministic and stochastic machine learning algorithms and investigating estimation and inference in the presence of possibly misspecified probability models. | Statistical Machine Learning A Unified Framework

GBP 99.99
1

Model-Assisted Bayesian Designs for Dose Finding and Optimization Methods and Applications

Model-Assisted Bayesian Designs for Dose Finding and Optimization Methods and Applications

Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of subsequent phase II and III trials. The objective of this book is to describe the state-of-the-art model-assisted designs to facilitate and accelerate the use of novel adaptive designs for early phase clinical trials. Model-assisted designs possess avant-garde features where superiority meets simplicity. Model-assisted designs enjoy exceptional performance comparable to more complicated model-based adaptive designs yet their decision rules often can be pre-tabulated and included in the protocol—making implementation as simple as conventional algorithm-based designs. An example is the Bayesian optimal interval (BOIN) design the first dose-finding design to receive the fit-for-purpose designation from the FDA. This designation underscores the regulatory agency's support of the use of the novel adaptive design to improve drug development. Features Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials Describes the up-to-date theory and practice for model-assisted designs Presents many practical challenges issues and solutions arising from early-phase clinical trials Illustrates with many real trial applications Offers numerous tips and guidance on designing dose finding and optimization trials Provides step-by-step illustrations of using software to design trials Develops a companion website (www. trialdesign. org) to provide freely available easy-to-use software to assist learning and implementing model-assisted designs Written by internationally recognized research leaders who pioneered model-assisted designs from the University of Texas MD Anderson Cancer Center this book shows how model-assisted designs can greatly improve the efficiency and simplify the design conduct and optimization of early-phase dose-finding trials. It should therefore be a very useful practical reference for biostatisticians clinicians working in clinical trials and drug regulatory professionals as well as graduate students of biostatistics. Novel model-assisted designs showcase the new KISS principle: Keep it simple and smart! | Model-Assisted Bayesian Designs for Dose Finding and Optimization Methods and Applications

GBP 84.99
1