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The Global Politics of Artificial Intelligence

Algebraic Number Theory and Fermat's Last Theorem

Algebraic Number Theory and Fermat's Last Theorem

Updated to reflect current research Algebraic Number Theory and Fermat’s Last Theorem Fourth Edition introduces fundamental ideas of algebraic numbers and explores one of the most intriguing stories in the history of mathematics—the quest for a proof of Fermat’s Last Theorem. The authors use this celebrated theorem to motivate a general study of the theory of algebraic numbers from a relatively concrete point of view. Students will see how Wiles’s proof of Fermat’s Last Theorem opened many new areas for future work. New to the Fourth EditionProvides up-to-date information on unique prime factorization for real quadratic number fields especially Harper’s proof that Z(√14) is EuclideanPresents an important new result: Mihăilescu’s proof of the Catalan conjecture of 1844Revises and expands one chapter into two covering classical ideas about modular functions and highlighting the new ideas of Frey Wiles and others that led to the long-sought proof of Fermat’s Last TheoremImproves and updates the index figures bibliography further reading list and historical remarksWritten by preeminent mathematicians Ian Stewart and David Tall this text continues to teach students how to extend properties of natural numbers to more general number structures including algebraic number fields and their rings of algebraic integers. It also explains how basic notions from the theory of algebraic numbers can be used to solve problems in number theory. | Algebraic Number Theory and Fermat's Last Theorem

GBP 39.99
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Computer Systems Architecture

Computer Systems Architecture

Computer Systems Architecture provides IT professionals and students with the necessary understanding of computer hardware. It addresses the ongoing issues related to computer hardware and discusses the solutions supplied by the industry. The book describes trends in computing solutions that led to the current available infrastructures tracing the initial need for computers to recent concepts such as the Internet of Things. It covers computers’ data representation explains how computer architecture and its underlying meaning changed over the years and examines the implementations and performance enhancements of the central processing unit (CPU). It then discusses the organization hierarchy and performance considerations of computer memory as applied by the operating system and illustrates how cache memory significantly improves performance. The author proceeds to explore the bus system algorithms for ensuring data integrity input and output (I/O) components methods for performing I/O various aspects relevant to software engineering and nonvolatile storage devices such as hard drives and technologies for enhancing performance and reliability. He also describes virtualization and cloud computing and the emergence of software-based systems’ architectures. Accessible to software engineers and developers as well as students in IT disciplines this book enhances readers’ understanding of the hardware infrastructure used in software engineering projects. It enables readers to better optimize system usage by focusing on the principles used in hardware systems design and the methods for enhancing performance.

GBP 44.99
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Data Science AI and Machine Learning in Drug Development

Data Science AI and Machine Learning in Drug Development

The confluence of big data artificial intelligence (AI) and machine learning (ML) has led to a paradigm shift in how innovative medicines are developed and healthcare delivered. To fully capitalize on these technological advances it is essential to systematically harness data from diverse sources and leverage digital technologies and advanced analytics to enable data-driven decisions. Data science stands at a unique moment of opportunity to lead such a transformative change. Intended to be a single source of information Data Science AI and Machine Learning in Drug Research and Development covers a wide range of topics on the changing landscape of drug R & D emerging applications of big data AI and ML in drug development and the build of robust data science organizations to drive biopharmaceutical digital transformations. Features Provides a comprehensive review of challenges and opportunities as related to the applications of big data AI and ML in the entire spectrum of drug R & D Discusses regulatory developments in leveraging big data and advanced analytics in drug review and approval Offers a balanced approach to data science organization build Presents real-world examples of AI-powered solutions to a host of issues in the lifecycle of drug development Affords sufficient context for each problem and provides a detailed description of solutions suitable for practitioners with limited data science expertise | Data Science AI and Machine Learning in Drug Development

GBP 99.99
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Randomized Phase II Cancer Clinical Trials

Randomized Phase II Cancer Clinical Trials

In cancer research a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy. Randomized Phase II Cancer Clinical Trials explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm phase II trials and many phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized phase II trials and describes statistical methods for both single-arm and randomized phase II trials. Although the text focuses on phase II cancer clinical trials the statistical methods covered can also be used (with minor modifications) in phase II trials for other diseases and in phase III cancer clinical trials. Suitable for cancer clinicians and biostatisticians this book shows how randomized phase II trials with a prospective control resolve the shortcomings of traditional single-arm phase II trials. It provides readers with numerous statistical design and analysis methods for randomized phase II trials in oncology.

GBP 44.99
1

Machine Learning for Healthcare Handling and Managing Data

Machine Learning for Healthcare Handling and Managing Data

Machine Learning for Healthcare: Handling and Managing Data provides in-depth information about handling and managing healthcare data through machine learning methods. This book expresses the long-standing challenges in healthcare informatics and provides rational explanations of how to deal with them. Machine Learning for Healthcare: Handling and Managing Data provides techniques on how to apply machine learning within your organization and evaluate the efficacy suitability and efficiency of machine learning applications. These are illustrated in a case study which examines how chronic disease is being redefined through patient-led data learning and the Internet of Things. This text offers a guided tour of machine learning algorithms architecture design and applications of learning in healthcare. Readers will discover the ethical implications of machine learning in healthcare and the future of machine learning in population and patient health optimization. This book can also help assist in the creation of a machine learning model performance evaluation and the operationalization of its outcomes within organizations. It may appeal to computer science/information technology professionals and researchers working in the area of machine learning and is especially applicable to the healthcare sector. The features of this book include: A unique and complete focus on applications of machine learning in the healthcare sector. An examination of how data analysis can be done using healthcare data and bioinformatics. An investigation of how healthcare companies can leverage the tapestry of big data to discover new business values. An exploration of the concepts of machine learning along with recent research developments in healthcare sectors. | Machine Learning for Healthcare Handling and Managing Data

GBP 115.00
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Handbook of Spin Transport and Magnetism

Handbook of Spin Transport and Magnetism

In the past several decades the research on spin transport and magnetism has led to remarkable scientific and technological breakthroughs including Albert Fert and Peter Grünberg’s Nobel Prize-winning discovery of giant magnetoresistance (GMR) in magnetic metallic multilayers. Handbook of Spin Transport and Magnetism provides a comprehensive balanced account of the state of the art in the field known as spin electronics or spintronics. It reveals how key phenomena first discovered in one class of materials such as spin injection in metals have been revisited decades later in other materials systems including silicon organic semiconductors carbon nanotubes graphene and carefully engineered nanostructures. The first section of the book offers a historical and personal perspective of the field written by Nobel Prize laureate Albert Fert. The second section addresses physical phenomena such as GMR in hybrid structures of ferromagnetic and normal metals. The third section discusses recent developments in spin-dependent tunneling including magnetic tunnel junctions with ferroelectric barriers. In the fourth section the contributors look at how to control spin and magnetism in semiconductors. In the fifth section they examine phenomena typically found in nanostructures made from metals superconductors molecular magnets carbon nanotubes quantum dots and graphene. The final section covers novel spin-based applications including advanced magnetic sensors nonvolatile magnetoresistive random access memory and semiconductor spin-lasers. The techniques and materials of spintronics have rapidly evolved in recent years leading to vast improvements in hard drive storage and magnetic sensing. With extensive cross-references between chapters this seminal handbook provides a complete guide to spin transport and magnetism across various classes of materials and structures.

GBP 44.99
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The History of the International Biometric Society

The History of the International Biometric Society

The International Biometric Society (IBS) was formed at the First International Biometric Conference at Woods Hole on September 6 1947. The History of the International Biometric Society presents a deep dive into the voluminous archival records with primary focus on IBS’s first fifty years. It contains numerous photos and extracts from the archival materials and features many photos of important leaders who served IBS across the decades. Features: Describes events leading up to and at Woods Hole on September 6 1947 that led to the formation of IBS Outlines key markers that shaped IBS after the 1947 formation through to the modern day Describes the regional and national group structure and the formation of regions and national groups Describes events surrounding the key scientific journal of IBS Biometrics including the transfer of ownership to IBS content editors policies management and importance Describes the other key IBS publications – Biometric Bulletin Journal of Agricultural Biological and Environmental Statistics and regional publications Provides details of International Biometric Conferences and key early symposia Describes IBS constitution and by-laws processes and the evolution of business arrangements Provides a record of international officers including regional presidents national group secretaries journal editors and the locations of meetings Includes a gallery of international Presidents and a gallery of Secretaries and Treasurers The History of the International Biometric Society will appeal to anyone interested in the activities of our statistical and biometrical forebearers. The focus is on issues and events that engaged the attention of the officers of IBS. Some of these records are riveting some entertaining some intriguing and some colorful. Some of the issues covered were difficult to handle but even these often resulted in changes that benefited IBS.

GBP 44.99
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