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Extremophiles From Biology to Biotechnology

Extremophiles From Biology to Biotechnology

Highly recommended by CHOICE Oct 2018Extremophiles are nature’s ultimate survivors thriving in environments ranging from the frozen Antarctic to abyssal hot hydrothermal vents. Their lifeforms span bacteria to fishes and are categorized as halophiles from hypersaline environments acidophiles from acidic waters psychrophiles from cold habitats and thermophiles from warm waters. Extremophiles: From Biology to Biotechnology comprehensively covers the basic biology physiology habitats secondary metabolites for bioprospecting and biotechnology of these extreme survivors. The chapters focus on the novel genetic and biochemical traits that lend these organisms to biotechnological applications. Couples studies of marine extremophile biology/genomics and extremophile culture for biotechnological applications with the latest advances in bio-prospecting and bio-product developmentIncludes practical experiments that a laboratory can use to replicate extreme habitats for research purposesPresents latest advances in extremophile genomics to give the reader a better understanding of the regulatory mechanisms of extremophilesOffers insights into the production of commercially important extremozymes carotenoids bioactive compounds and secondary metabolites of medicinal value. This unique guide serves as a resource for biotechnologists who wish to explore extremophiles for their commercial potential as well as a valuable reference for teaching undergraduate graduate and postgraduate students. | Extremophiles From Biology to Biotechnology

GBP 48.99
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Animation From Concepts and Production

Kava From Ethnology to Pharmacology

Cancer Inhibitors from Chinese Natural Medicines

Nanotherapeutics From Laboratory to Clinic

Nanotherapeutics From Laboratory to Clinic

The emergence of nanotherapeutics is attributable to the integration of nanotechnology recombinant DNA technology and synthetic organic chemistry with medicine for treating critical human diseases in a more efficient and specific molecular approach than therapy with conventionally-designed and formulated drugs. Nanotherapeutics: From Laboratory to Clinic comprehensively discusses the current shortcomings for delivery of classical (small) drugs macromolecular therapeutics and recombinant vaccine via the common intravascular and extravascular routes. The book describes the synthetic/chemical engineering methods as well as recombinant hybridoma and phage display technologies to fabricate different types of nanoparticulate carriers and drugs. It also reveals the diversified approaches undertaken by harnessing nanotechnology to overcome the multistep extracellular and intracellular barriers and to facilitate the development of novel strategies for therapeutic delivery and imaging. The author elaborates on the preclinical and clinical trials of potential nanoparticle-based products in animal models and patients and the approval/commercialization of nanotherapeutics addressing all relevant human diseases. A focus on the above issues in a concise but illustrative manner fills the gap between the laboratory findings originating from the research on identification of cellular and systemic barriers of classical and macromolecular drugs along with development of strategies for fabrication and testing of nanotherapeutics and the clinical outcomes emanating from the testing of the selected potential nanotherapeutics on patients of particular diseases. The book also fills a gap in the existing literature between the design and development of diversified nanotherapeutics for various purposes and the investigation and evaluation of potential barriers and resultant therapeutic efficacy of those nano-medicine formulations. | Nanotherapeutics From Laboratory to Clinic

GBP 44.99
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Energy from Waste Production and Storage

Structural Design from First Principles

Structural Design from First Principles

This enlightening textbook for undergraduates on civil engineering degree courses explains structural design from its mechanical principles showing the speed and simplicity of effective design from first principles. This text presents good approximate solutions to complex design problems such as Wembley-Arch type structures the design of thin-walled structures and long-span box girder bridges. Other more code-based textbooks concentrate on relatively simple member design and avoid some of the most interesting design problems because code compliant solutions are complex. Yet these problems can be addressed by relatively manageable techniques. The methods outlined here enable quick early stage ball-park design solutions to be considered and are also useful for checking finite element analysis solutions to complex problems. The conventions used in the book are in accordance with the Eurocodes especially where they provide convenient solutions that can be easily understood by students. Many of the topics such as composite beam design are straight applications of Eurocodes but with the underlying theory fully explained. The techniques are illustrated through a series of worked examples which develop in complexity with the more advanced questions forming extended exam type questions. A comprehensive range of fully worked tutorial questions are provided at the end of each section for students to practice in preparation for closed book exams. | Structural Design from First Principles

GBP 48.99
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Environmental Exposure From Chemicals Volume II

Magnetic Nanoparticles From Fabrication to Clinical Applications

Multiscale Modeling From Atoms to Devices

Multiscale Modeling From Atoms to Devices

While the relevant features and properties of nanosystems necessarily depend on nanoscopic details their performance resides in the macroscopic world. To rationally develop and accurately predict performance of these systems we must tackle problems where multiple length and time scales are coupled. Rather than forcing a single modeling approach to predict an event it was not designed for a new paradigm must be employed: multiscale modeling. A brilliant solution to a pervasive problem Multiscale Modeling: From Atoms to Devices offers a number of approaches for which more than one scale is explicitly considered. It provides several alternatives from coarse-graining sampling of the atomic and mesoscale to Monte Carlo- and thermodynamic-based models that allow sampling of increasingly large scales up to multiscale models able to describe entire devices. Beginning with common techniques for coarse-graining the book discusses their theoretical background advantages and limitations. It examines the application-dependent parameterization characteristics of coarse-graining along with the finer-trains-coarser multiscale approach and describes three carefully selected examples in which the parameterization although based on the same principles depends on the actual application. The book considers the use of ab initio and density functional theory to obtain parameters needed for larger scale models the alternative use of density functional theory parameters in a Monte Carlo method and the use of ab initio and density functional theory as the atomistic technique underlying the calculation of thermodynamics properties of alloy phase stability. Highlighting one of the most challenging tasks for multiscale modelers Multiscale Modeling: From Atoms to Devices also presents modeling for nanocomposite materials using the embedded fiber finite element method (EFFEM). It emphasizes an ensemble Monte Carlo method to high field-charge transport problems and demonstrates the practical application of modern many-body quantum theories. The author maintains a website with additional information. | Multiscale Modeling From Atoms to Devices

GBP 69.99
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Translational Pain Research From Mouse to Man

Translational Pain Research From Mouse to Man

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer osteoarthritis fibromyalgia and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing endocannabinoids cannabis gene therapy siRNA gene studies and the role of glia cytokines P2X receptors and ATP this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences. | Translational Pain Research From Mouse to Man

GBP 69.99
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Quantitative Biology From Molecular to Cellular Systems

Quantitative Biology From Molecular to Cellular Systems

Quantitative methods are revolutionizing modern molecular and cellular biology. Groundbreaking technical advances are fueling the rapid expansion in our ability to observe as seen in multidisciplinary studies that integrate theory computation experimental assays and the control of microenvironments. Integrating new experimental and theoretical methods Quantitative Biology: From Molecular to Cellular Systems gives both new and established researchers a solid foundation for starting work in this field. The book is organized into three sections:Fundamental Concepts covers bold ideas that inspire novel approaches in modern quantitative biology. It offers perspectives on evolutionary dynamics system design principles chance and memory and information processing in biology. Methods describes recently developed or improved techniques that are transforming biological research. It covers experimental methods for studying single-molecule biochemistry small-angle scattering from biomolecules subcellular localization of proteins and single-cell behavior. It also describes theoretical methods for synthetic biology and modeling random variations among cells. Molecular and Cellular Systems focuses on specific biological systems where modern quantitative biology methods are making an impact. It incorporates case studies of biological systems for which new concepts or methods are increasing our understanding. Examples include protein kinase at the molecular level the genetic switch of phage lambda at the regulatory system level and Escherichia coli chemotaxis at the cellular level. In short Quantitative Biology presents practical tools for the observation modeling design and manipulation of biological systems from the molecular to the cellular levels. | Quantitative Biology From Molecular to Cellular Systems

GBP 51.99
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Transcriptomics from Aquatic Organisms to Humans

Polysaccharide Gums from Agricultural Products Processing Structures and Functionality

Swarm Intelligence From Social Bacteria to Humans

Swarm Intelligence From Social Bacteria to Humans

The notion of swarm intelligence was introduced for describing decentralized and self-organized behaviors of groups of animals. Then this idea was extrapolated to design groups of robots which interact locally to cumulate a collective reaction. Some natural examples of swarms are as follows: ant colonies bee colonies fish schooling bird flocking horse herding bacterial colonies multinucleated giant amoebae Physarum polycephalum etc. In all these examples individual agents behave locally with an emergence of their common effect. An intelligent behavior of swarm individuals is explained by the following biological reactions to attractants and repellents. Attractants are biologically active things such as food pieces or sex pheromones which attract individuals of swarm. Repellents are biologically active things such as predators which repel individuals of swarm. As a consequence attractants and repellents stimulate the directed movement of swarms towards and away from the stimulus respectively. It is worth noting that a group of people such as pedestrians follow some swarm patterns of flocking or schooling. For instance humans prefer to avoid a person considered by them as a possible predator and if a substantial part of the group in the situation of escape panic (not less than 5%) changes the direction then the rest follows the new direction too. Some swarm patterns are observed among human beings under the conditions of their addictive behavior such as the behavior of alcoholics or gamers. The methodological framework of studying swarm intelligence is represented by unconventional computing robotics and cognitive science. In this book we aim to analyze new methodologies involved in studying swarm intelligence. We are going to bring together computer scientists and cognitive scientists dealing with swarm patterns from social bacteria to human beings. This book considers different models of simulating controlling and predicting the swarm behavior of different species from social bacteria to humans. | Swarm Intelligence From Social Bacteria to Humans

GBP 58.99
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Cell Membrane Nanodomains From Biochemistry to Nanoscopy

Cell Membrane Nanodomains From Biochemistry to Nanoscopy

Cell Membrane Nanodomains: From Biochemistry to Nanoscopy describes recent advances in our understanding of membrane organization with a particular focus on the cutting-edge imaging techniques that are making these new discoveries possible. With contributions from pioneers in the field the book explores areas where the application of these novel techniques reveals new concepts in biology. It assembles a collection of works where the integration of membrane biology and microscopy emphasizes the interdisciplinary nature of this exciting field. Beginning with a broad description of membrane organization including seminal work on lipid partitioning in model systems and the roles of proteins in membrane organization the book examines how lipids and membrane compartmentalization can regulate protein function and signal transduction. It then focuses on recent advances in imaging techniques and tools that foster further advances in our understanding of signaling nanoplatforms. The coverage includes several diffraction-limited imaging techniques that allow for measurements of protein distribution/clustering and membrane curvature in living cells new fluorescent proteins novel Laurdan analyses and the toolbox of labeling possibilities with organic dyes. Since superresolution optical techniques have been crucial to advancing our understanding of cellular structure and protein behavior the book concludes with a discussion of technologies that are enabling the visualization of lipids proteins and other molecular components at unprecedented spatiotemporal resolution. It also explains the ins and outs of the rapidly developing high- or superresolution microscopy field including new methods and data analysis tools that exclusively pertain to these techniques. This integration of membrane biology and advanced imaging techniques emphasizes the interdisciplinary nature of this exciting field. The array of contributions from leading world experts makes this book a valuable tool for the visualization of signaling nanoplatforms by means of cutting-edge optical microscopy tools. | Cell Membrane Nanodomains From Biochemistry to Nanoscopy

GBP 44.99
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Metal-Organic Framework Nanocomposites From Design to Application

Fluoride Removal from Groundwater by Adsorption Technology

Fluoride Removal from Groundwater by Adsorption Technology

In the Eastern corridor of Northern region of Ghana presence of high fluoride concentration in the groundwater has made many drilled boreholes unusable for drinking. Little is however known about the factors contributing to the occurrence of high fluoride in this part of Ghana and it’s spatial distribution. Treatment of the fluoride-contaminated groundwater by adsorption is also hampered by the lack of suitable adsorbents that are locally available. Based on principal component analysis and saturation indices calculations this thesis highlights that the predominant mechanisms controlling the fluoride enrichment probably include calcite precipitation and Na/Ca exchange processes both of which deplete Ca from the groundwater and promote the dissolution of fluorite. The mechanisms also include F-/OH- anion exchange processes as well as evapotranspiration processes which concentrate the fluoride ions hence increasing its concentration in the groundwater. Spatial mapping showed that the high fluoride groundwaters occur predominantly in the Saboba Cheriponi and Yendi districts. The thesis further highlights that modifying the surface of indigenous materials by an aluminium coating process is a very promising approach to develop a suitable fluoride adsorbent. Aluminum oxide coated media reduced fluoride in water from 5. 0 ± 0. 2 mg/L to ≤ 1. 5 mg/L (which is the WHO health based guideline for fluoride) in both batch and continuous flow column experiments in the laboratory. Kinetic and isotherm studies thermodynamic calculations as well as analytical results from Fourier Transform Infrared Spectroscopy and Raman spectroscopy suggest the mechanism of fluoride adsorption onto aluminium oxide coated media involved both physisorption and chemisorption processes. Field testing in a fluoritic community in Northern Ghana showed that the adsorbent is also capable of treating fluoride-contaminated groundwater in field conditions suggesting it is a promising defluoridation adsorbent. The adsorbent also showed good regenerability potential that would allow re-use which could make it practically and economically viable. Additional research is however required to further increase the fluoride adsorption capacity of developed adsorbent. | Fluoride Removal from Groundwater by Adsorption Technology

GBP 82.99
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Veterinary Clinical Epidemiology From Patient to Population

Veterinary Clinical Epidemiology From Patient to Population

4* Doody's Review! Ideal for veterinary students residents and clinicians the fourth edition of this bestselling textbook has been fully updated in line with developments in research and teaching. The logical chapter progression reflects the stages in a clinical case work-up and how epidemiological concepts and methods contribute. This new edition provides guidelines for improving patient and population health outcomes and detecting emerging diseases through systematic evaluation of patient encounters and electronic medical records incorporates new methodologies and concepts drawn from the recent veterinary practice literature updates chapter content including expanded coverage of risk statistical and economic analyses and surveillance for emerging diseases more than 60 examples of clinical research drawn from the international veterinary practice literature presented as structured abstracts; follow-up questions invite the reader to participate in the analysis of results online links to full text versions of more than half of structured abstracts and more than 40% of the book’s 174 literature citations updates the listing and review of public and private online resources including guidelines for online literature searching and critical evaluation of clinical reports. Today’s veterinary curricula places greater emphasis on experiential/problem-based learning versus discipline-oriented instruction. This fourth edition is ideally suited to introduce epidemiologic concepts and methodologies to veterinary students in the context of the patient encounter and should be of use at any point in the veterinary curriculum. | Veterinary Clinical Epidemiology From Patient to Population

GBP 82.99
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Human-Wildlife Interactions From Conflict to Coexistence

Human-Wildlife Interactions From Conflict to Coexistence

This book won the 2023 The Wildlife Society Publication Award in the authored book category. Human-wildlife interactions increase exponentially as more and more humans and wildlife crowd into the same limited space. Such interactions often become conflicts when wildlife threaten human health and safety well-being or the food supply. This second edition of Human-Wildlife Interactions: From Conflict to Coexistence provides a comprehensive review of the severity of these problems and the methods used to resolve clashes between humans and wildlife. During his forty-year career as a wildlife professor and scientist Dr. Michael Conover founder of journal Human-Wildlife Interactions has become a recognized leader of the scientific field of human-wildlife interactions. In this book he presents the range of methods for wildlife damage management including employing lethal methods; distributing supplemental food; changing the behavior of either humans or wildlife; and excluding or repelling wildlife. Backed by numerous case studies and informative side bars the book documents resolutions to specific human-wildlife conflicts throughout the literature. Containing full color illustrations throughout the second edition of Human-Wildlife Interactions: From Conflict to Coexistence provides authoritative coverage and depth of both theoretical and practical information. It serves as an invaluable resource for students researchers and professional wildlife managers. Disclaimer: Figure 7. 7 (b) on page 251 was incorrectly attributed in previous printings. The photographer of figure 7. 7 (b) is Cynthia Herrick. | Human-Wildlife Interactions From Conflict to Coexistence

GBP 56.99
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Cenozoic Seas The View From Eastern North America