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The Law of Off-label Uses of Medicines - Andrea Parziale - Bog - Taylor & Francis Ltd - Plusbog.dk

The Law of Off-label Uses of Medicines - Andrea Parziale - Bog - Taylor & Francis Ltd - Plusbog.dk

This book examines the regulatory framework for untested and unapproved uses (off-label uses) of medicines in the EU, UK, and USA. Before reaching patients, medicines are extensively tested by manufacturers and approved by regulators to minimise the risk of adverse reactions. However, physicians can prescribe pharmaceuticals for off-label uses, widespread in paediatrics, oncology, rare diseases and, more recently, in treatment for Covid-19. While off-label uses may offer hope, they may also expose patients to risks and uncertainties. Clarification is therefore needed to improve the protection of patients'' rights while enhancing legal certainty for health actors. To this end, this work clarifies the regulatory mechanisms and litigation trends concerning off-licence prescriptions in these jurisdictions. It assesses how traditional, prevention-driven regulatory and civil liability rules are being adapted to tackle potential risks and scientific uncertainty. The book outlines the applicable regulations, as well as considering Brexit’s impact on off-label policies in the UK, and EU and national off-label policies in the context of the fight against the Covid-19 pandemic. It also explores under what conditions physicians, manufacturers, or regulators must compensate patients injured by untested prescriptions. The book will be an essential resource for researchers, academics and policy-makers working in the areas of medical law and ethics, public health law, pharmaceutical law and private comparative law.

DKK 422.00
1

Label-Free Biosensors - - Bog - Cambridge University Press - Plusbog.dk

Label-Free Biosensors - - Bog - Cambridge University Press - Plusbog.dk

Label-free biosensors are devices that use biological or chemical receptors to detect analytes (molecules) in a sample. They give detailed information on the selectivity, affinity, and, in many cases, also the binding kinetics and thermodynamics of an interaction. Although they can be powerful tools in the hands of a skilled user, there is often a lack of knowledge of the best methods for using label-free assays to screen for biologically active molecules and accurately and precisely characterize molecular recognition events. This book reviews both established and newer label-free techniques giving both the expert user and the general reader interested in the technologies and applications behind label-free an insight into the field from expert opinion leaders and practitioners of the technologies. Most importantly, chapters contain worked examples from leaders in the field that take the reader through the basics of experimental design, setup, assay development, and data analysis.

DKK 740.00
1

Multi-Label Dimensionality Reduction - Jieping (arizona State University Ye - Bog - Taylor & Francis Inc - Plusbog.dk

Multi-Label Dimensionality Reduction - Jieping (arizona State University Ye - Bog - Taylor & Francis Inc - Plusbog.dk

Similar to other data mining and machine learning tasks, multi-label learning suffers from dimensionality. An effective way to mitigate this problem is through dimensionality reduction, which extracts a small number of features by removing irrelevant, redundant, and noisy information. The data mining and machine learning literature currently lacks a unified treatment of multi-label dimensionality reduction that incorporates both algorithmic developments and applications. Addressing this shortfall, Multi-Label Dimensionality Reduction covers the methodological developments, theoretical properties, computational aspects, and applications of many multi-label dimensionality reduction algorithms. It explores numerous research questions, including: - - How to fully exploit label correlations for effective dimensionality reduction - How to scale dimensionality reduction algorithms to large-scale problems - How to effectively combine dimensionality reduction with classification - How to derive sparse dimensionality reduction algorithms to enhance model interpretability - How to perform multi-label dimensionality reduction effectively in practical applications - The authors emphasize their extensive work on dimensionality reduction for multi-label learning. Using a case study of Drosophila gene expression pattern image annotation, they demonstrate how to apply multi-label dimensionality reduction algorithms to solve real-world problems. A supplementary website provides a MATLAB ® package for implementing popular dimensionality reduction algorithms.

DKK 993.00
1

Off Off Broadway Festival Plays, 13th Series - Bernie Deleo - Bog - Samuel French Ltd - Plusbog.dk

Off Off Broadway Festival Plays, 13th Series - Bernie Deleo - Bog - Samuel French Ltd - Plusbog.dk

A collection of short plays selected by New York theatre critics, professionals, and the editorial staff of Samuel French, Inc. as the most important plays in the 13th Annual Off Off Broadway Original Short Play Festival, sponsored by Double Image Productions. The Samuel French Off Off Broadway Short Play Festival fosters the work of early-career writers, giving them exposure throughpublication and representation. This collection includes: No Problem by Catherine Butterfield, A Grave Encounter

DKK 172.00
1

From Label to Table - Xaq Frohlich - Bog - University of California Press - Plusbog.dk

From Label to Table - Xaq Frohlich - Bog - University of California Press - Plusbog.dk

How did the Nutrition Facts label come to appear on millions of everyday American household food products? As Xaq Frohlich reveals, this legal, scientific, and seemingly innocuous strip of information can be a prism through which to view the high-stakes political battles and development of scientific ideas that have shaped the realms of American health, nutrition, and public communication. By tracing policy debates at the U.S. Food and Drug Administration, Frohlich describes the emergence of our present information age in food and diet markets and examines how powerful government offices inform the public about what they consume. From Label to Table explores evolving popular ideas about food, diet, and responsibility for health that have influenced what goes on the Nutrition Facts label—and who gets to decide that.

DKK 252.00
1

From Label to Table - Xaq Frohlich - Bog - University of California Press - Plusbog.dk

From Label to Table - Xaq Frohlich - Bog - University of California Press - Plusbog.dk

How did the Nutrition Facts label come to appear on millions of everyday American household food products? As Xaq Frohlich reveals, this legal, scientific, and seemingly innocuous strip of information can be a prism through which to view the high-stakes political battles and development of scientific ideas that have shaped the realms of American health, nutrition, and public communication. By tracing policy debates at the U.S. Food and Drug Administration, Frohlich describes the emergence of our present information age in food and diet markets and examines how powerful government offices inform the public about what they consume. From Label to Table explores evolving popular ideas about food, diet, and responsibility for health that have influenced what goes on the Nutrition Facts label—and who gets to decide that.

DKK 811.00
1

Read the Label! - Richard Emerson - Bog - Ebury Publishing - Plusbog.dk

Read the Label! - Richard Emerson - Bog - Ebury Publishing - Plusbog.dk

Do you know the difference between ''Use by'' and ''Best before''? Or what is meant by ''Farmhouse'' or ''Home-made''? And did you know that 75% of the salt we consume each day is added by food manufacturers during preparation or processing? Read the Label! is a must-have reference book that exposes the reality of food labelling and provides comprehensive information on how food manufacturers can manipulate the facts. With an in-depth examination of the common ingredients found in our foods, information on how far you can trust the food label and clear guidance on how to make an informed decision about the products you buy, this book will change the way you shop forever.

DKK 159.00
1

Major Label Mastering - Evren Goeknar - Bog - Taylor & Francis Ltd - Plusbog.dk

Major Label Mastering - Evren Goeknar - Bog - Taylor & Francis Ltd - Plusbog.dk

Major Label Mastering: Professional Mastering Process distills 25 years of mastering experience at Capitol Records into practical understandings and reliable systems. Containing unparalleled insights, this book reveals the mastering tricks and techniques used by Evren Göknar at one of the world’s most notable record labels. Beginning with the requisite competencies every Mastering Engineer must develop, Major Label Mastering delves into the particulars of the mastering studio, as well as fundamental mastering tools. Included among these tools is The Five Step Mastering Process, a rigorously tested system that equips the practitioner to successfully and confidently master a project to exacting standards of audio fidelity. Covering all bases, the book discusses both macro and micro considerations: from mindset approach and connecting with clients down to detailed guidelines for processing audio, advanced methods, and audio restoration. Each chapter ends with exercises intended to deepen understanding and skill, or to supplement course study. Suitable for all levels, this is a unique resource for students, artists, and recording and Mastering Engineers alike. Major Label Mastering is supplemented by digital resources including audio examples and video tutorials.

DKK 410.00
1

Off Off Broadway Festival Plays, 43rd Series - Gracie Gardner - Bog - Samuel French Ltd - Plusbog.dk

Off Off Broadway Festival Plays, 43rd Series - Gracie Gardner - Bog - Samuel French Ltd - Plusbog.dk

One of Manhattan’s most established play festivals, the Samuel French Off Off Broadway Short Play Festival fosters the work of emerging writers, giving them the exposure of publication and representation. The 43rd collection includes: Rabiosa by Nelson Diaz-MarcanoThe Forgotten Place by Jeff LockerBaked Goods by Charlie Cohen, Helen Park, and Christyn BudzynaBallgirl by Gracie GardnerBetter by Vince GattonThe Ferberizing of Coral by Patrick Flynn

DKK 160.00
1

Off Off Broadway Festival Plays, 17th Series - Judd Silverman - Bog - Samuel French Ltd - Plusbog.dk

Off Off Broadway Festival Plays, 17th Series - Judd Silverman - Bog - Samuel French Ltd - Plusbog.dk

A collection of short plays selected by New York theatre critics, professionals, and the editorial staff of Samuel French, Inc. as the most important plays of the 17th Annual Off Off Broadway Original Short Play Festival, sponsored by Love Creek Productions. This collection includes: Correct Address by Judd Silverman, Cowboys, Indians & Waitresses by Raymond King Shurtz, Homebound by Lyndall Callahan, The Road to Nineveh by Le Wilhelm, Your Life is a Feature Film by Alan Minieri

DKK 172.00
1