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The Law of Off-label Uses of Medicines - Andrea Parziale - Bog - Taylor & Francis Ltd - Plusbog.dk

The Law of Off-label Uses of Medicines - Andrea Parziale - Bog - Taylor & Francis Ltd - Plusbog.dk

This book examines the regulatory framework for untested and unapproved uses (off-label uses) of medicines in the EU, UK, and USA. Before reaching patients, medicines are extensively tested by manufacturers and approved by regulators to minimise the risk of adverse reactions. However, physicians can prescribe pharmaceuticals for off-label uses, widespread in paediatrics, oncology, rare diseases and, more recently, in treatment for Covid-19. While off-label uses may offer hope, they may also expose patients to risks and uncertainties. Clarification is therefore needed to improve the protection of patients'' rights while enhancing legal certainty for health actors. To this end, this work clarifies the regulatory mechanisms and litigation trends concerning off-licence prescriptions in these jurisdictions. It assesses how traditional, prevention-driven regulatory and civil liability rules are being adapted to tackle potential risks and scientific uncertainty. The book outlines the applicable regulations, as well as considering Brexit’s impact on off-label policies in the UK, and EU and national off-label policies in the context of the fight against the Covid-19 pandemic. It also explores under what conditions physicians, manufacturers, or regulators must compensate patients injured by untested prescriptions. The book will be an essential resource for researchers, academics and policy-makers working in the areas of medical law and ethics, public health law, pharmaceutical law and private comparative law.

DKK 422.00
1

Label-Free Biosensors - - Bog - Cambridge University Press - Plusbog.dk

Label-Free Biosensors - - Bog - Cambridge University Press - Plusbog.dk

Label-free biosensors are devices that use biological or chemical receptors to detect analytes (molecules) in a sample. They give detailed information on the selectivity, affinity, and, in many cases, also the binding kinetics and thermodynamics of an interaction. Although they can be powerful tools in the hands of a skilled user, there is often a lack of knowledge of the best methods for using label-free assays to screen for biologically active molecules and accurately and precisely characterize molecular recognition events. This book reviews both established and newer label-free techniques giving both the expert user and the general reader interested in the technologies and applications behind label-free an insight into the field from expert opinion leaders and practitioners of the technologies. Most importantly, chapters contain worked examples from leaders in the field that take the reader through the basics of experimental design, setup, assay development, and data analysis.

DKK 740.00
1

Major Label Mastering - Evren Goeknar - Bog - Taylor & Francis Ltd - Plusbog.dk

Major Label Mastering - Evren Goeknar - Bog - Taylor & Francis Ltd - Plusbog.dk

Major Label Mastering: Professional Mastering Process distills 25 years of mastering experience at Capitol Records into practical understandings and reliable systems. Containing unparalleled insights, this book reveals the mastering tricks and techniques used by Evren Göknar at one of the world’s most notable record labels. Beginning with the requisite competencies every Mastering Engineer must develop, Major Label Mastering delves into the particulars of the mastering studio, as well as fundamental mastering tools. Included among these tools is The Five Step Mastering Process, a rigorously tested system that equips the practitioner to successfully and confidently master a project to exacting standards of audio fidelity. Covering all bases, the book discusses both macro and micro considerations: from mindset approach and connecting with clients down to detailed guidelines for processing audio, advanced methods, and audio restoration. Each chapter ends with exercises intended to deepen understanding and skill, or to supplement course study. Suitable for all levels, this is a unique resource for students, artists, and recording and Mastering Engineers alike. Major Label Mastering is supplemented by digital resources including audio examples and video tutorials.

DKK 410.00
1

Spin-Label Electron Paramagnetic Resonance Spectroscopy - Derek Marsh - Bog - Taylor & Francis Ltd - Plusbog.dk

Spin-Label Electron Paramagnetic Resonance Spectroscopy - Derek Marsh - Bog - Taylor & Francis Ltd - Plusbog.dk

Spin-label electron paramagnetic resonance (EPR) spectroscopy is a versatile molecular probe method that finds wide application in molecular biophysics and structural biology. This book provides the first comprehensive summary of basic principles, spectroscopic properties, and use for studying biological membranes, protein folding, supramolecular structure, lipid-protein interactions, and dynamics. The contents begin with discussion of fundamental theory and practice, including static spectral parameters and conventional continuous-wave (CW) spectroscopy. The development then progresses, via nonlinear CW-EPR for slower motions, to the more demanding time-resolved pulse EPR, and includes an in-depth treatment of spin relaxation and spectral line shapes. Once the spectroscopic fundamentals are established, the final chapters acquire a more applied character. Extensive appendices at the end of the book provide detailed summaries of key concepts in magnetic resonance and chemical physics for the student reader and experienced practitioner alike. Key Features: - Indispensable reference source for the understanding and interpretation of spin-label spectroscopic data in its different aspects. Tables of fundamental spectral parameters are included throughout. - Forms the basis for an EPR graduate course, extending up to a thorough coverage of advanced topics in Specialist Appendices. Includes all necessary theoretical background. The primary audience is research workers in the fields of molecular biophysics, structural biology, biophysical chemistry, physical biochemistry and molecular biomedicine. Also, physical chemists, polymer physicists, and liquid-crystal researchers will benefit from this book, although illustrative examples used are often taken from the biomolecular field. Readers will be postgraduate researchers and above, but include those from other disciplines who seek to understand the primary spin-label EPR literature.

DKK 496.00
1

Looking behind the Label - Gustavo Setrini - Bog - Indiana University Press - Plusbog.dk

Looking behind the Label - Gustavo Setrini - Bog - Indiana University Press - Plusbog.dk

What does it mean when consumers "shop with a conscience" and choose products labeled as fair or sustainable? Does this translate into meaningful changes in global production processes? To what extent are voluntary standards implemented and enforced, and can they really govern global industries? Looking behind the Label presents an informative introduction to global production and ethical consumption, tracing the links between consumers' choices and the practices of multinational producers and retailers. Case studies of several types of products—wood and paper, food, apparel and footwear, and electronics—are used to reveal what lies behind voluntary rules and to critique predominant assumptions about ethical consumption as a form of political expression.

DKK 606.00
1

Off the Grid - Professor Phillip Vannini - Bog - Taylor & Francis Ltd - Plusbog.dk

Off the Grid - Professor Phillip Vannini - Bog - Taylor & Francis Ltd - Plusbog.dk

Off-grid isn’t a state of mind. It isn’t about someone being out of touch, about a place that is hard to get to, or about a weekend spent offline. Off-grid is the property of a building (generally a home but sometimes even a whole town) that is disconnected from the electricity and the natural gas grid. To live off-grid, therefore, means having to radically re-invent domestic life as we know it, and this is what this book is about: individuals and families who have chosen to live in that dramatically innovative, but also quite old, way of life. This ethnography explores the day-to-day lives of people in each of Canada’s provinces and territories living off the grid. Vannini and Taggart demonstrate how a variety of people, all with different environmental constraints, live away from contemporary civilization. The authors also raise important questions about our social future and whether off-grid living creates an environmentally and culturally sustainable lifestyle practice. These homes are experimental labs for our collective future, an intimate look into unusual contemporary domestic lives, and a call to the rest of us leading ordinary lives to examine what we take for granted. This book is ideal for courses on the environment and sustainability as well as introduction to sociology and introduction to cultural anthropology courses.

DKK 403.00
1

Check It Off! - Vera Teller - Bog - Rowman & Littlefield - Plusbog.dk

Check It Off! - Vera Teller - Bog - Rowman & Littlefield - Plusbog.dk

Check It Off! Pave Your Way through College to Career is an excellent resource for high-school students entering college and a great read for parents too! Vera Teller, a college lecturer of first-year seminars, shows readers what they need to do in college to prepare themselves to seek employment and obtain a career once graduated. Check It Off! provides a checklist of activities for each year of college to prepare the student for a career and to help him or her answer the three most important questions:1. What do I like to do?2. What do I want to do?3. What does the world need?This book is a quick, easy read that uniquely focuses on the activities students should pursue during college rather than after college. Check It Off! provides a proactive approach to career planning that steers the student to explore activities in preparation of a career and career direction.

DKK 399.00
1

Taking Off Domestic Building Construction - Andrew Atkinson - Bog - Taylor & Francis Ltd - Plusbog.dk

Taking Off Domestic Building Construction - Andrew Atkinson - Bog - Taylor & Francis Ltd - Plusbog.dk

This book provides a detailed step-by-step guide to taking off building work. It is pitched at a basic introductory level especially suitable for technicians entering the construction industry from school, perhaps intending to follow a trade or technical career. An ideal workbook for students of quantity surveying, construction and civil engineering when learning to measure building work. It introduces students to the most basic aspects of measurement and prepares them for learning the more complex areas of taking off. The book works through examples based on the measurement of a simple traditional pair of semi-detached (duplex) houses, with the relevant construction technology explained throughout. Although the format largely follows United Kingdom taking-off practice and conventions, it will be directly applicable to international practice in countries broadly following United Kingdom conventions. Each chapter presents a worked example from the substructure, through to masonry walls, upper floors, roofing, internal finishes, windows and doors. The examples are matched to an exercise for students and include a commentary of why and how the take-off work is being done. Concentrating specifically on the skilled task of taking off, the examples are designed to give confidence and practice rather than theoretical knowledge. This practical book is ideal for use on the Design, Surveying and Planning T Level; HNC Construction; and undergraduate and non-cognate postgraduate courses in Quantity Surveying, Construction and Building Surveying.

DKK 420.00
1

The Off-Screen - Eyal Peretz - Bog - Stanford University Press - Plusbog.dk

The Off-Screen - Eyal Peretz - Bog - Stanford University Press - Plusbog.dk

From the Renaissance on, a new concept of the frame becomes crucial to a range of artistic media, which in turn are organized around and fascinated by this frame. The frame decontextualizes, cutting everything that is within it from the continuity of the world and creating a realm we understand as the realm of fiction. The modern theatrical stage, framed paintings, the novel, the cinematic screen—all present us with such framed-off zones. Naturally, the frame creates a separation between inside and out. But, as this book argues, what is outside the frame, what is offstage, or off screen, remains particularly mysterious. It constitutes the primary enigma of the work of art in the modern age. It is to the historical and conceptual significance of this "off" that this book is dedicated. By focusing on what is outside the frame of a work of art, it offers a comprehensive theory of film, a concise history of American cinema from D.W. Griffith to Quentin Tarantino, and a reflection on the place and significance of film within the arts of modernity in general.

DKK 584.00
1