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Randomized Phase II Cancer Clinical Trials - Sin Ho Jung - Bog - Taylor & Francis Inc - Plusbog.dk

In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy. Randomized Phase II Cancer Clinical Trials explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm phase II trials and many phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized phase II trials and describes statistical methods for both single-arm and randomized phase II trials. Although the text focuses on phase II cancer clinical trials, the statistical methods covered can also be used (with minor modifications) in phase II trials for other diseases and in phase III cancer clinical trials. Suitable for cancer clinicians and biostatisticians, this book shows how randomized phase II trials with a prospective control resolve the shortcomings of traditional single-arm phase II trials. It provides readers with numerous statistical design and analysis methods for randomized phase II trials in oncology.

ARM Assembly Language - William Hohl - Bog - Taylor & Francis Inc - Plusbog.dk

ARM Microprocessor Systems - Muhammad Tahir - Bog - Taylor & Francis Inc - Plusbog.dk

This book presents the use of a microprocessor-based digital system in our daily life. Its bottom-up approach ensures that all the basic building blocks are covered before the development of a real-life system. The ultimate goal of the book is to equip students with all the fundamental building blocks as well as their integration, allowing them to implement the applications they have dreamed up with minimum effort.

A Systematic Approach to Learning Robot Programming with ROS - Wyatt (case Western Reserve University Newman - Bog - Taylor & Francis Inc - Plusbog.dk

A Systematic Approach to Learning Robot Programming with ROS provides a comprehensive, introduction to the essential components of ROS through detailed explanations of simple code examples along with the corresponding theory of operation. The book explores the organization of ROS, how to understand ROS packages, how to use ROS tools, how to incorporate existing ROS packages into new applications, and how to develop new packages for robotics and automation. It also facilitates continuing education by preparing the reader to better understand the existing on-line documentation. The book is organized into six parts. It begins with an introduction to ROS foundations, including writing ROS nodes and ROS tools. Messages, Classes, and Servers are also covered. The second part of the book features simulation and visualization with ROS, including coordinate transforms. The next part of the book discusses perceptual processing in ROS. It includes coverage of using cameras in ROS, depth imaging and point clouds, and point cloud processing. Mobile robot control and navigation in ROS is featured in the fourth part of the book The fifth section of the book contains coverage of robot arms in ROS. This section explores robot arm kinematics, arm motion planning, arm control with the Baxter Simulator, and an object-grabber package. The last part of the book focuses on system integration and higher-level control, including perception-based and mobile manipulation. This accessible text includes examples throughout and C++ code examples are also provided at https://github.com/wsnewman/learning_ros

Playing Video Games - - Bog - Taylor & Francis Inc - Plusbog.dk

From security training simulations to war games to role-playing games, to sports games to gambling, playing video games has become a social phenomena, and the increasing number of players that cross gender, culture, and age is on a dramatic upward trajectory. Playing Video Games: Motives, Responses, and Consequences integrates communication, psychology, and technology to examine the psychological and mediated aspects of playing video games. It is the first volume to delve deeply into these aspects of computer game play. It fits squarely into the media psychology arm of entertainment studies, the next big wave in media studies. The book targets one of the most popular and pervasive media in modern times, and it will serve to define the area of study and provide a theoretical spine for future research.This unique and timely volume will appeal to scholars, researchers, and graduate students in media studies and mass communication, psychology, and marketing.

Noninferiority Testing in Clinical Trials - Tie Hua Ng - Bog - Taylor & Francis Inc - Plusbog.dk

Take Your NI Trial to the Next Level Reflecting the vast research on noninferiority (NI) designs from the past 15 years, Noninferiority Testing in Clinical Trials: Issues and Challenges explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a clinical trial. Requiring no prior knowledge of NI testing, the book is easily accessible to both statisticians and nonstatisticians involved in drug development. With over 20 years of experience in this area, the author introduces the basic elements of the NI trials one at a time in a logical order. He discusses issues with estimating the effect size based on historical placebo control trials of the active control. The book covers fundamental concepts related to NI trials, such as assay sensitivity, constancy assumption, discounting, and preservation. It also describes patient populations, three-arm trials, and the equivalence of three or more groups.

Downtown Planning for Smaller and Midsized Communities - Philip Walker - Bog - Taylor & Francis Inc - Plusbog.dk

"For so long we were floundering and taking ad hoc measures, but the minute I understood what a downtown plan really was I said ''We need one of those!'' As it turned out, it was the most fantastic vehicle I''ve ever seen," said Susan Moffat-Thomas of New Bern, North Carolina. Her hometown got a much-needed shot in the arm from a good downtown plan. Does yours need a similar boost? The Author, an experienced downtown-planning consultant, offers practical tips for preserving a sense of place, improving fiscal efficiency, and enhancing quality of life in Downtown Planning for Smaller and Midsized Communities. Planners and revitalization officials will learn how to address physical components of the downtown, as well as economic development. The Author, an experienced downtown-planning consultant, also explains how to develop an organization to implement a downtown plan; how federal, state, and local policies may influence the planning process; and how to fund a downtown revitalization effort.

Resistance and Revenge - Jacques Derogy - Bog - Taylor & Francis Inc - Plusbog.dk

Initially published in French under the title Operation Nemesis , this revealing work is a study of the Armenian Revolutionary Federation and the individuals responsible for the execution of Turkish leaders involved in the Armenian Genocide of 1915. Derogy''s rigorous research and detective work bring to life the disciplined effort by Armenian nationalists to seek retribution for historic crimes against the Armenian people. The work richly details Turkish plans for the liquidation of the Armenian people, the individuals selected to assassinate the genocidists, and documents for the first time the role of the organized Armenian political opposition to Turkish rule. In doing so, Derogy brings to light the relationship between the legal party and its extra-legal arm; the mechanisms needed to implement the daring plan of assassination; and the special post-war circumstances in which the Armenian nation found itself torn asunder by a Turkish-Soviet detente, in which the independence of Armenia became the sacrificial pawn. Derogy worked closely with scholars around the world and interviewed first-hand survivors who had direct contact with the events described. His is a detective story of the first rank and a historical reconstruction of an obscured chapter of Armenian history.

Fix Your Supply Chain - Paul Husby - Bog - Taylor & Francis Inc - Plusbog.dk

Written by business leaders for business leaders, this book explores successful supply chain improvement requirements and improvement methodologies, along with their strengths and limitations. It covers the use of these techniques in a story about Twin City Manufacturing, a fictitious company based on the authors’ actual experiences. The principles put forth in this volume show how to enable and sustain long-term change. Whether you are intimately familiar with the supply chain discipline or have limited experience, the authors provide a valuable roadmap that can be applied to supply chain improvement. Drawing from their combined 70 years of experience with supply chain–related functions, they explore seven factors that can help a company become one of the few that truly achieve and maintain operational excellence. 1. Top company leadership 2. Improvement methodology 3. Continuous improvement strategy 4. The cause and the vision 5. The Sustainable Improvement Roadmap 6. Enablement of sustainability 7. Constancy of purpose Operational excellence is required to make any winning business strategy sustainable, but it is only achieved and sustained through continuous improvement, and these improvements must be real. This book will arm you with the knowledge and methods needed to identify needed change and the tools to implement them, and perhaps most importantly, give you the confidence needed to become an effective change agent.

LeanSpeak - Mary A. Junewick - Bog - Taylor & Francis Inc - Plusbog.dk

This dictionary, specific to lean business processes, contains over 500 terms used in lean management and manufacturing. Easy to access, accurate, and comprehensive, LeanSpeak will become the desktop tool of choice for lean manufacturing practitioners, from the shop floor to the corner office. Here are some examples of entries in LeanSpeak: gemba: Japanese word of which the literal translation is "the real place." In the manufacturing field, gemba means the shop floor, where the actual product is being made, as contrasted to the office, where support services are provided. lean: shorthand to refer to a lean manufacturing system, of which the Toyota Production System is the foremost example, that has relatively little non-value-adding waste and maximum flow. The term has been used pejoratively to refer to anti-labor practices intending to reduce the number of workers within a company and to strong-arm tactics with suppliers. takt time: the rate at which product must be turned out to satisfy market demand. It is determined by dividing the available production time by the rate of customer demand. For example, if customers demand 240 widgets per day and the factory operates 480 minutes per day, takt time is two minutes. If customers want two new products designed per month, takt time is two weeks. It is a calculated number, not a reflection of your capability. It sets the pace of production to match the rate of customer demand. Also available as an ebook in Microsoft Reader, Adobe Acrobat Reader, or Palm Reader formats.

Payment Due - Timothy J Penny - Bog - Taylor & Francis Inc - Plusbog.dk

T he generational wars are about to begin: competing for entitlements, wrestling over taxes, dancing around the deficit. Today’s children and grandchildren are tomorrow’s taxpayers and social fabric. The authors of Payment Due contend that our current policies of federal overspending are setting those children up for economic disaster. Former Representative Tim Penny (D-MN) knows how volatile the politics of the situation are; he retired because he couldn’t locate in Congress at large the institutional will (or stomach) to deal with the issues squarely. Political scientist Steven Schier understands the way in which the politics work against economics to solve the problem. Together, they take us inside the Capitol corridors to show us the lobbying, arm-twisting, and pork barrel politicking that goes on to derail policies designed to reduce the federal deficit. We get to play the “Washington Monument game” along with the worst of the offenders and to see firsthand how three schools of deficit thought—the wolves, pussycats, and termites—approach the prospect of cutting back federal outlays and weaning the great middle class from its own welfare dependency. A hallmark of the book is its three-tiered set of long-term entitlement reform proposals, complete with careful documentation of the contribution each recommended item makes toward reducing the federal deficit (or at least slowing its increase). Along with suggested short-term plans, these proposals give students the opportunity to try to solve both short- and long-term problems. Students will appreciate the timeliness and relevance of the book’s argument to their generation’s future plight, and all readers will benefit from the clear presentation of complex economic concepts and arguments essential to understanding the federal deficit debate—and to confronting the political, social, and moral payments now coming due.

The Laboratory Zebrafish - Christian (children's Hospital Boston Lawrence - Bog - Taylor & Francis Inc - Plusbog.dk

Like other books in the Laboratory Animal Pocket Reference Series , this guide covers all aspects pertaining to the use of these organisms including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management. In the relatively brief span of only a few decades, the zebrafish has gone from being mainly a hobby fish to a mainstream model animal employed by scientists to study everything from stem cells to the basis of behavioral changes induced by drug addiction. This rapid advance has been fueled largely by numerous and impressive advances in technology, along with detailed characterization of the animal on a genetic and molecular level. These developments have allowed scientists to leverage the many advantages of the zebrafish system to address many important questions in biology and human genetics and disease. However, there are few accepted and established standards for husbandry, management, and care for the fish in laboratory settings and even fewer comprehensive and constantly reliable resources. To this end, the goal of this handbook is to provide managers, veterinarians, investigators, technicians, and regulatory personnel with a concise yet thorough reference on zebrafish biology, care, husbandry, and management. The aim of the book is not to set standards, but rather to arm those working with the fish with scientifically grounded principles and fundamental information that can be used to design sound fish care programs. This handbook is organized into seven chapters: Biology Husbandry Life Support Systems Management Veterinary Care Experimental Methodology Resources The final chapter, Resources , provides the zebrafish user with lists of sources of additional information on the zebrafish model, as well as key references, professional organizations, and suppliers of equipment and supplies used in zebrafish husbandry and care.

Quest For The Jade Sea - Pascal James Imperato - Bog - Taylor & Francis Inc - Plusbog.dk

The last of the major African lakes to be visited by European travelers in the late nineteenth century, Lake Rudolf lies in the eastern arm of the great Rift Valley in present-day northern Kenya, near the Ethiopian border. Also known as Lake Turkana, Lake Rudolf is a large saltwater body two hundred miles long and forty miles wide. Fed by the Omo River that flows south from the Ethiopian highlands, it is surrounded by an inhospitable landscape of extinct volcanoes, wind-driven semidesert, and old lava flows. Because of the greenish hue of its waters, it has long been called the Jade Sea.Quest for the Jade Sea examines the fascinating story of colonial competition around this remote lake. Pascal James Imperato''s account yields important insights into European colonial policies in East Africa in the late nineteenth century and how these policies came into conflict with a powerful indigenous and independent African state, Ethiopia, which itself was engaged in imperial expansion.Although the chief competitors for the lake included the British, Italians, the French, Russians, and Ethiopians, its colonial fate was decided by Great Britain and Ethiopia. The role of Ethiopia as a late nineteenth-century colonial power unfolds as Imperato provides unique insights and analyses of Ethiopian colonial policy and its effects on the peoples who inhabited the region of the lake.As well as examining the political and diplomatic aspects of colonial competition for Lake Rudolf, Quest for the Jade Sea focuses on the expeditions that traveled there. Many of these were the field expressions of colonial policy; others were undertaken in the interest of scientific and geographical discovery. Whatever the impetus, their success required courage and much suffering on the part of those who led them. Whether as willing agents of larger colonial designs, soldiers intent on promoting their military careers, or explorers who wished to advance scientific knowledge, expedition leaders left behind not only fascinating chronicles of their experiences and discoveries but also parts of the larger story of colonial competition around an East African lake.