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Insulin Resistance - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Insulin Resistance - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Now in a revised and expanded second edition, this unique text presents topics related to insulin resistance in youth and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of insulin resistance in children and what is known about how insulin resistance in youth differs from adults, the measurement of insulin resistance in youth in the research and clinical settings, and current knowledge regarding the epidemiology of insulin resistance in the pediatric population. The second section of the book explores pathophysiology, including current knowledge of the molecular, metabolic, and physiologic mechanisms of insulin resistance, the unique pathophysiology of pregnancy and puberty, the contributions of the prenatal and early childhood environment to the development of insulin resistance, and adipose and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular disease and liver disorders. A third section, new to this second edition, explores insulin resistance in unique models: intrauterine growth restriction and girls with polycystic ovary syndrome and metabolic syndrome. The final section of the book explores the concepts of treatment through medications directed at insulin sensitivity, as well as exercise, weight loss medications and consequences of bariatric surgery. Insulin Resistance: Childhood Precursors of Adult Disease, Second Edition provides up-to-date reviews of all of these areas, providing the reader with a current perspective on issues in insulin resistance in youth, an emerging risk factor for disease across the lifespan, that will spur continued interest in the topic on the part of clinicians and researchers, perhaps promoting new points of view and creative approaches to this daunting challenge.

DKK 967.00
1

Cultural Representations of Gender Vulnerability and Resistance - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Theorizing Heritage through Non-Violent Resistance - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Nonviolent Resistance and Democratic Consolidation - Felix S. Bethke - Bog - Springer Nature Switzerland AG - Plusbog.dk

Current Applications for Overcoming Resistance to Targeted Therapies - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Resistance and Colonialism - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Resistance and Colonialism - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Resistance to Political Violence in Latin America - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Resistance to Political Violence in Latin America - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Art, Religion and Resistance in (Post-)Communist Romania - Maria Alina Asavei - Bog - Springer Nature Switzerland AG - Plusbog.dk

Civil Resistance and Violent Conflict in Latin America - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Gender, Resistance and Transnational Memories of Violent Conflicts - Pauline Stoltz - Bog - Springer Nature Switzerland AG - Plusbog.dk

Risking Antimicrobial Resistance - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Maternal Abandonment and Queer Resistance in Twenty-First-Century Swedish Literature - Jenny Bjoerklund - Bog - Springer Nature Switzerland AG -

Resistance Training Methods - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Resistance to Targeted Therapies in Lymphomas - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Resistance to Targeted Therapies in Lymphomas - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Over the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.

DKK 816.00
1

Resistance to Targeted Therapies in Lymphomas - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Resistance to Targeted Therapies in Lymphomas - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Over the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.

DKK 816.00
1

Border Regimes, Racialisation Processes and Resistance in Germany - Fazila Bhimji - Bog - Springer Nature Switzerland AG - Plusbog.dk

Mobility, Spatiality, and Resistance in Literary and Political Discourse - - Bog - Springer Nature Switzerland AG - Plusbog.dk

Exploring Single Black Mothers' Resistance Through Homeschooling - Cheryl Fields Smith - Bog - Springer Nature Switzerland AG - Plusbog.dk