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Phage Display as a Tool for Synthetic Biology - Santina Carnazza - Bog - Nova Science Publishers Inc - Plusbog.dk

Phage Display as a Tool for Synthetic Biology - Santina Carnazza - Bog - Nova Science Publishers Inc - Plusbog.dk

Phage display can be considered as a practical realisation of an artificial chemical evolution. As such, it is an useful tool for in vitro protein evolution, aimed to identifying new receptors and natural ligands for "orphan receptors", drug discovery (peptides might act as enzyme inhibitors and receptor agonists or antagonists, or otherwise modulate the enzyme/receptor''s biological effect), "epitope discovery" (a new approach to disease diagnosis and vaccine development), design of DNA-binding proteins, source of new materials, antibody phage and recombinant phage probes, next-generation nano-electronics, targeted therapy, molecular imaging, gene delivery and phage-display vaccination. All this can be regarded as a kind of synthetic biology in that it involves the reshaping and redirecting of natural molecular systems, phage, typically using the tools of protein and genetic engineering.

DKK 633.00
1

Recent Advances in Flexible Organic Light-Emitting Devices - Wen Wen - Bog - Nova Science Publishers Inc - Plusbog.dk

Recent Advances in Flexible Organic Light-Emitting Devices - Wen Wen - Bog - Nova Science Publishers Inc - Plusbog.dk

White organic light-emitting devices (WOLED''s) are of considerable interest owing to their attractive characteristics and potential application to flat panel display and solid-state lighting source. Currently WOLED''s are the new increasing point in the area of organic optoelectronics due to their high power efficiency. After a brief overview of the WOLED''s operating principles and basic emitting structure, this book presents a review of recent progress in WOLED''s structure and materials.

DKK 534.00
1

Television Standards? - - Bog - Nova Science Publishers Inc - Plusbog.dk

Television Standards? - - Bog - Nova Science Publishers Inc - Plusbog.dk

The Federal Communications Commission (FCC) has been bombarded with hundreds of thousands of complaints concerning the 2004 Super Bowl halftime show. Although the focal point of the complaints has been a public breast exposure, the complaints perhaps reflect the general outrage at a halftime show which has been described as a raunchy and disgraceful public display of indecency. The National Football League took a huge risk with its franchise presentation which has already reached over 100 million viewers. The FCC, however, is supposed to function as the guardian of what passes for a certain level of public decency and cultural acceptability. But has it been doing that or has it deteriorated to a little more than a back-water refuge for nepotism and industry fawning? This book presents media analyses of what the FCC is supposed to do -- not what it does based on results.

DKK 445.00
1

Chronic Pain - - Bog - Nova Science Publishers Inc - Plusbog.dk

Chronic Pain - - Bog - Nova Science Publishers Inc - Plusbog.dk

In the opening chapter of Chronic Pain: Prevalence, Management and Outcomes, the authors examine how the health care professional might psychologically approach the management of chronic pain. The nocebo effect of some communications will be highlighted, as well as ways to utilise the patient''s internal resources to reduce emotional distress. Following this, a study exploring pain coping mechanisms amongst Maltese chronic pain patients is presented. Semi-structured interviews were conducted with 21 participants, and findings derived from a grounded theory methodology revealed that Maltese often display reluctance to rely on pharmacological therapies. The authors address the need for pain treatment, the reduced interference of interventional pain management, the increase of patient self-efficacy, and methods of acceptance for some chronic pain. The closing chapter analyzes 3,434 scheduled prescription drug records for 94 chronic back pain patients from a single clinic, comparing 52 patients enrolled in the New Mexico Medical Cannabis Program with 42 non-enrolled patients over a 24 month period.

DKK 624.00
1

Screening & Brief Intervention for the Reduction of Alcohol-Impaired Driving - - Bog - Nova Science Publishers Inc - Plusbog.dk

Screening & Brief Intervention for the Reduction of Alcohol-Impaired Driving - - Bog - Nova Science Publishers Inc - Plusbog.dk

Only a small fraction of the impaired drivers who are at risk for alcohol-impaired-driving crashes are arrested. These include drivers who drink regularly or occasionally to intoxication before they drive. Researchers have estimated the probability of being arrested while driving while intoxicated (DWI) with a blood alcohol concentration at or above .10 g/dL to be about 1 in 200. A similar study reported that only 23% of alcohol-positive drivers admitted to trauma units and emergency departments following crashes are convicted of DWI. This book provides an overview of the use of Screening and Brief Intervention (SBI) as a countermeasure for those who have displayed, or could potentially display, harmful/hazardous drinking behaviours, including drinking and driving. This book endeavours to acquaint the highway safety community with an overview of the development of SBI, the context in which SBI is employed, the efficacy and limitations of this approach, and the policy implications for traffic safety.

DKK 722.00
1

Features of the Optical Materials Modified with the Effective Nanoobjects - - Bog - Nova Science Publishers Inc - Plusbog.dk

Features of the Optical Materials Modified with the Effective Nanoobjects - - Bog - Nova Science Publishers Inc - Plusbog.dk

New effective nano-objects such as the fullerenes, carbon nanotubes, shungites, graphenes and quantum dots have been widely used now in the research of many scientific and technical groups. The main reason to use the fullerenes, shungites, and quantum dots is connected to their unique energy levels and the high value of electron affinity energy. The basic features of carbon nanotubes and graphenes are regarded to their high conductivity, strong hardness of their C-C bonds as well as complicated and unique mechanisms of charge carrier moving. These peculiarities of carbon nano-objects will be under consideration in this paper to explain their influence on balk and surface optical materials properties with good new advantages. As the result of this discussion and investigation, new areas of application of the nanostructured optical materials and elements can be shown in the optoelectronics and laser optics, medicine, telecommunications, display, microscopy technique, etc. Moreover, the nanostructured materials can be used for example, for development of transparent UV and IR window, for gas storage and solar energy accumulation, as well as in airspace and atomic industry.

DKK 722.00
1

Aphasia - - Bog - Nova Science Publishers Inc - Plusbog.dk

Aphasia - - Bog - Nova Science Publishers Inc - Plusbog.dk

Aphasia is a language disorder in which there is an impairment (but not loss) of speech and of comprehension of speech. Depending on the area and extent of the damage, someone suffering from aphasia may be able to speak but not write, or vice versa, or display any of a wide variety of other deficiencies in language comprehension and production. This book will review grammatical world class processing by aphasic individuals and bilingual aphasia, each of which is essential to an understanding of the topic. This book will also examine the role of the right hemisphere for language processing and successful therapeutic interventions in aphasic patients. Furthermore, new findings for the understanding of neural processes involved in the recovery of language functions in aphasic subjects are discussed. This book also expands and improves upon the currently accepted methodology used in the diagnosis of dementia, particularly when aphasia is a core symptom. Finally, dual-route models and right-hemispheric accounts are examined to predict comprehension of figurative language in healthy speakers as well as in patients with language disorders.

DKK 1079.00
1

Building an Intelligent Assisted Instructional Design System - Jun Ming Su - Bog - Nova Science Publishers Inc - Plusbog.dk

Building an Intelligent Assisted Instructional Design System - Jun Ming Su - Bog - Nova Science Publishers Inc - Plusbog.dk

With the rapid growth of Internet, E-learning systems have become more and more popular because they can enable learners to study at any time and any location, so the need of learning resources and instructional design is also increasing rapidly. Many international standards have been proposed to model the structures and guiding rules of learning activities for the purpose of sharing and reusing. However, there are still no effective models to describe complex instructional design knowledge, and the effective authoring systems of instructional design and learning content navigating sequence are also required. Moreover, without an intelligent knowledge management scheme, the huge amount of learning resources will confuse the teachers in learning activity design. It implies that how to visualise and integrate the heterogeneous instructional design and navigating sequence knowledge in a learning platform becomes an important issue. Therefore, the author proposes an Intelligent Assisted Instructional Design System (IAIDS), which is an instructional design expert system consisting of Knowledge Representation (KR) module to model the instructional design graphically, knowledge acquisition (KA) module to assist teachers to edit instructional design and navigating sequence efficiently, Knowledge Management (KM) module to support teachers to manage and retrieve learning contents in repositories, and Knowledge Inference (KI) module to display the learning activity in a portable and modifiable platform.

DKK 514.00
1

Our Loving Relationship - William A Lambos - Bog - Nova Science Publishers Inc - Plusbog.dk

Our Loving Relationship - William A Lambos - Bog - Nova Science Publishers Inc - Plusbog.dk

For any healthy individual or couple experiencing a difficult, problematic or less than enjoyable loving relationship in today''s crazy world (and who hasn''t?) -- this book is perfect for you. The primary focus is on mutual ("us", "we", and "me and you") issues pertinent to loving relationships -- the couple and their relationship. Using case vignettes from the authors'' clinical experiences as psychologists, the first 14 chapters address the loving relationship topics of Love, Loving, Our Pasts, Relationship Analysis, Congruence and Balance, Outside Factors and Features, Other People, Needs and Wants, Expectations and Dependence, Boundaries and Control, Lifestyles, Monetary and Equity Issues, and Problems, and Relationship Skills. The last three address where to look for more help when serious situations arise: Seeing a Professional Counsellor, Therapist or Family Mediator, How a Professional Counsellor or Therapist Can be Helpful to You, and Some Suggestions About Getting Help from a Professional. The book is very reader-friendly, simplistic, solution-focused and down to earth, and also includes 39 Figures from their case files that graphically display the issues and helpful recommendations. The book''s authors, with many years of experience as psychologists, professors and scholars, conceptualise loving relationships and improving them as representing developmental processes that are best seen as a kind of ongoing and ever-evolving "dance" between two individuals -- relationships are not events! Reading this book will contribute to, enrich and enhance any individual''s or couple''s developmental processes -- and especially themselves and their relationship.

DKK 465.00
1

My Loving Relationships - William A Lambos - Bog - Nova Science Publishers Inc - Plusbog.dk

My Loving Relationships - William A Lambos - Bog - Nova Science Publishers Inc - Plusbog.dk

For any individual who has wondered how a perfectly sane person in today''s crazy world is supposed to figure out what is expected of them when navigating a loving relationship (and who hasn''t?), this book is a must-read. The primary focus is on those issues most pertinent to the individual -- "I", "me", and "you" issues -- relevant to the quest for satisfying, loving relationships. Using case vignettes from the authors'' clinical experiences as psychologists, the book''s first 15 chapters address the topics of Self Analysis, Relationship Analysis, My Past, Behaviour Analysis, Dichotomous Thinking, Patterns and Trends, Divorce and Separation, Guilt and Shame, Fears and Phobias, Depression, Grieving, Time and Timing, Happiness and Joy, and The Internet (the Good, the Bad, and the Ugly). The last three address where to look for more help when serious situations arise: Seeing a Professional Counsellor, Therapist or Family Mediator, How a Professional Counsellor or Therapist Can be Helpful to You, and Some Suggestions About Getting Help from a Professional. The book is very reader-friendly, solution-focused and down to earth, and also includes 43 Figures from the author''s case files that graphically display the issues and helpful recommendations. The book''s authors, with many years of experience as psychologists, professors and scholars, conceptualise loving relationships and improving them as representing developmental processes that are best seen as a kind of ongoing and ever-evolving "dance" between two individuals -- relationships are not events! Reading this book will contribute to, enrich and enhance any individual''s developmental process -and especially themselves and their loving relationships.

DKK 465.00
1

Advances in Audiology Research - - Bog - Nova Science Publishers Inc - Plusbog.dk

Advances in Audiology Research - - Bog - Nova Science Publishers Inc - Plusbog.dk

Genes causing hearing loss display various modes of inheritance, with autosomal recessive being the most common. With so many cases of hearing loss having a genetic etiology, audiologists are certain to encounter these patients on a fairly regular basis. Audiologists who possess basic knowledge about genetics are better equipped to recognize when a genetics referral is warranted, thereby enhancing patient care. In this chapter, it is determined that a genetics evaluation can yield valuable information for patients and their families, such as prognosis, estimates of recurrence risks, and diagnosis of other family members. The second chapter will review causes of revision surgery, how to diagnose cases of failed cochlear implants and will discuss surgical and audiological outcome of revision cochlear implant surgeries, Speech recognition ability with a replacement cochlear implant may significantly increase or decrease from that with the original implant. Experienced cochlear implant patients facing reimplantation must be counseled regarding the possibility of differences in sound quality and speech recognition performance with their replacement device. The purpose of the following chapter is to correlate the results obtained through questionnaires concerning self-reported restriction in social participation and patient satisfaction / benefit with objective time assessment of device use. This is a descriptive, cross-sectional study sample composed of and elderly and non-elderly adults of both sexes diagnosed with hearing loss and approved as candidates for hearing aid fitting at a university hospital. The goal of chapter four is to understand the main features of human posture and how it is possible to analyze it. The aim of this chapter is to investigate the influence of hearing loss and vestibular disorders on body posture. The objective of the concluding chapter was to analyze the auditory brainstem response (ABR) and frequency following response (FFR) in patients diagnosed with Sickle Cell Disease (SCD) who were referred to the outpatient hemoglobinopathy clinic at a public hospital in southern Brazil.

DKK 718.00
1

Absolute & Chemical Electronegativity & Hardness - Mihai V Putz - Bog - Nova Science Publishers Inc - Plusbog.dk

Absolute & Chemical Electronegativity & Hardness - Mihai V Putz - Bog - Nova Science Publishers Inc - Plusbog.dk

Systematic formulations of absolute and chemical electronegativity and hardness are analysed among the local and non-local electronic density contributions in the frame of density functional theory. It is analytically proved that in all proposed cases can be founded the proper conditions within the absolute and chemical formulations to equalise. There appears that a new variational concept and term named as chemical action plays the unifying role among the quantum fluctuations of electronegativity and hardness at whatever level of atomic and molecular structural information. The power of these proofs consists in bypassing the knowledge of the total energy density functional. This way there was emerged out the new concepts of HOMO and LUMO chemical actions that neglecting the correlation-exchange terms account as the potential chemical works of the valence shells when exchanging electrons with the environment. As an application the associated atomic electronegativity, hardness and chemical action scales are computed and discussed for each unified quantum picture with the help of Slater orbitals. The so called bosonic electronegativity and hardness characterising the fermionic-bosonic mixtures on valence states emerge out and their associate atomic scales are computed. It follows that they display periodic albeit inverse trends than those expected from pure fermionic behaviour. This approach may be found most useful when explaining the Bose-Einstein condensates and superconductivity of atoms through electronegativity and hardness concepts. Extension to molecular systems is prospected by employing the recursive rules for electronegativity and hardness abstracted from electronegativity equalisation principle combined with electronegativity-hardness invariant. In this molecular framework the unified forms of electronegativity and hardness are used to complete the proposed bonding scenario based on equality and inequality electronegativity and hardness reactivity principles for a specific series of Lewis bases. New index for checking the maximum hardness condition is formulated and applied as well. This way, the complete set of global electronegativity-hardness indicators of reactivity of atoms and molecules for various physico-chemical conditions is formulated in an elegant analytical manner within the conceptual density functional theory.

DKK 534.00
1

Aromaticity - Maria J Gonzalez Moa - Bog - Nova Science Publishers Inc - Plusbog.dk

Aromaticity - Maria J Gonzalez Moa - Bog - Nova Science Publishers Inc - Plusbog.dk

Aromaticity is among the most frequently used concepts in the chemical literature. Nevertheless, it has to be stressed that aromaticity is not an observable that could be directly obtained from molecular wave function. So, it remains as a controversial concept and its physical origin is still being debated. This has lead to multiple ways for assessing the aromatic or anti-aromatic character of molecules. Thus, several indices of aromaticity have been proposed throughout the literature. It is well-known that aromaticity is strongly related to the electron delocalisation of the electrons along all the centres of the ring. The introduction of the n-order density matrix, and development of n-centre delocalisation indices (n-DIs), has provided a quantitative tool to measure electron delocalisation within a certain ring. Therefore, n-DIs can be regarded as a promising way to determine the actual role played by electron delocalisation in aromaticity. n-DIs are found to be in line with most of the qualitative trends predicted by the harmonic oscillator model of aromaticity indices, HOMAs, aromaticity indices derived from the Chemical Graph Theory, properties of the ring critical points, and circuit resonance energies. It has to be noticed that the direct comparison of n-DIs computed for rings with a different number of centers does not provide a picture of relative aromatic stabilisation. In fact, aromatic stabilisation does not only depend on the extension of the electron delocalisation over the n centres, but also on the number of centres. n-DIs dependence on the number of centres and electrons in a ring prevents to use their direct comparison as a measure of aromatic stabilisation unless an appropriate scaling is applied. Effective Scaled Electron Delocalisation indices, ESED, have been developed for comparing the total aromaticity of polyaromatic hydrocarbons. n-DIs exhibit very different behaviour for aromatic and antiaromatic hydrocarbons. Thus, an aromatic compound is one whose multicenter electron delocalisation is larger than that of the corresponding linear structure, whereas an antiaromatic compound is one where the multi-centre electron delocalisation is smaller than that of the linear molecule. Those compounds that display very small differences between linear and cyclic structures may be called non-aromatic. n-DIs are also found as a promising tool to study the aromaticity of transition states in concerted processes. This book also reports on its application to the study of the aromaticity in all metal compounds.

DKK 514.00
1

Estimating Parentage Relationships Using Molecular Markers in Aquaculture - Paulino Martinez - Bog - Nova Science Publishers Inc - Plusbog.dk

Estimating Parentage Relationships Using Molecular Markers in Aquaculture - Paulino Martinez - Bog - Nova Science Publishers Inc - Plusbog.dk

The inference of parentage relationships between individuals from their molecular resemblance represents a useful methodology for genetic improvement in Aquaculture. This makes possible the reorganisation of broodstock in groups with low relatedness, as well as the identification of families in selection programs to avoid the harmful effects of inbreeding and to maintain the highest diversity as possible across generations. The choice of the appropriate genetic marker and the statistical methodology is essential to get the best solution for the questions considered. Depending on the availability of previous information on the genealogy, paternity or kinship analysis will be applied. The simplest approach to paternity inference, involves parent identification through the exclusion of the remaining candidates. However, this can lead to more than one solution, solvable after application of maximum likelihood procedures. The ability to identify the parents of each offspring depends on the sampling scenario (number of candidate parents and the fraction sampled), on the potential of the markers used (polymorphism, genotyping errors), and on the conformance to theoretical assumptions of the statistical models applied. A large number of paternity programs are freely available. They display usually complementary performances, and there is not the best software for all situations. When the authors dealt with a single group of individuals belonging to the same generation or that could not be separated into known generations, the aim was just to estimate the degree of genetic relationship between them, usually expressed as the coancestry coefficient. The basic idea is to determine how much of the molecular similarity (Identity By State) is due to the Identity By Descent (the really important parameter). There are two groups of relationship estimators from the molecular information. One of them includes methods directed at estimating coancestry for only a pair of individuals at a time, usually relaying on the knowledge of the allele frequencies of the reference population. Estimators within this group can be further divided into those called Method of Moments Estimators (MME) and those based on Maximum Likelihood (MLE). The other group of methods uses jointly the information of all individuals to determine the more probable population/familiar structure. They perform an explicit reconstruction of the genealogy leading to the observed population (at least for one generation above). Depending on the type of estimator and the assumptions used in their development, each of them presents some advantages and/or limitations which should be taken into account when choosing the one to use. In the present study, the most relevant estimators are presented and, also, a list of free software available for their application.

DKK 529.00
1